Cameron and Rhea perform on different stages in Portland; in this rare chance to see each other, they still can't see enough of each other; Cameron realizes she needs a new opener and Rhea decides to join Cameron on tour.
At home between tour dates, Cameron and Rhea use the time to dive into wedding planning; after a miscommunication about whether they should have their friends Dave and Frances in the wedding party or not, Cameron and Rhea must get on the same page.
As Cameron and Rhea hit the road, they learn the realities of being two women on tour -- they get to celebrate with fans, but they also need to prioritize their safety; at Best Bet, Dave guest hosts for Cameron and Rhea and learns hard lessons.
Cameron and Rhea realize they both have clutter in their lives; Rhea keeps everything and has a closet overflowing with keepsakes that outlived their usefulness; Cameron clings to ex-girlfriends as one of them, Brie, moves to Los Angeles.
Leading up to their sets at Best Bet, three female comedians navigate their respective worlds as their experiences inform their comedy; in the green room, a somewhat clueless journalist interviews Cameron and Rhea about whether comedy matters.
After Cameron's wedding suit shows up unwearable and Rhea lands a last-minute audition for a TV show, they decide to call off their joint bachelor party; Miranda, Melina, Dave and Frances rush to their aid.
Cameron preps nervously for her stand-up special, accompanied by her ex-girlfriend Brie who barely survives a breakup; Rhea has the time of her life on the set of Bob's TV show, but she misses opening for Cameron on the biggest day of her career.
Recovering from Rhea letting Cameron down, a mishap at their planned wedding venue throws the couple into a panic; they have eight hours to forgive each other and find a new place to get married.