After learning her ex-husband Ben never cancelled their honeymoon, Mindy goes on a Oneymoon by herself and befriends a zany single like herself while struggling with her identity.
When Mindy finds out Annette has cancer, she tries to be there while Tamra struggles with adopting Morgan's religious practices that put a strain on their relationship, and Jody grasps with what he wants for his future.
Mindy and Danny can't agree on the best way to care for an ailing Annette. Meanwhile, Anna throws a bridal/baby shower for Tamra, where Colette has a heated confrontation with her brother, Jody.
In this series finale, Mindy struggles to find a new investor after learning she doesn't have enough money to keep her practice open on her own. Tamara and Morgan wed. Annette goes into surgery for her double mastectomy.