A a cardiothoracic transplant surgeon struggles to balance his personal life with his professional as he bids for an administrative position and tries to save a young girl's life.
Nathaniel must decide whether to operate on a recidivist alcoholic who has already rejected one liver, and Simon gets a lesson in the healing power of faith.
Kate interacts with a prisoner who is a potential donor, and one of Nate's patients returns with rejection, but no one can determine why it's occurring.
Kate works with a mother suspected of killing her child, although she claims her husband did it; Nate and Tom lock horns over an experimental procedure.
The hospital receives three potential donors from a shooting, but family react angrily when they find out the shooter may be donating as well; Simon talks a patient into splitting his donor liver with unexpected results.
Bart's son refuses to allow the DNR order, leaving Nate struggling between what Bart wants and what's best for the family; Jonas insists on doing a risky procedure, and begins to doubt himself when Simon bails him out.