You know what they say about good intentions.. Bio chemist scientists(and couple)Adrien Brody and Sarah Polley fool around with genetics by splicing animal and human DNA and the result will be devastating. Their work is supposed to be geared towards research which would lead to finding cures for all types of diseases and what these two create is a half-animal/half-human hybrid which is growing at an alarming rate. Polley grows attached to "Dren"(backwards for Nerd), almost a mother/daughter bond but as "she" evolves we see that it is becoming more unpredictable and dangerous not to mention the eventual "gender problem" which develops. A culmination of excellent computer generated and make-up effects highlights this sci-fi horror outing where, once again, science creates a threat to human kind, proving that despite the reasons behind their methods and experiments, it seems when you fool around with genetics only bad can come from it. Some disturbing/weird sex(and especially a bizarre rape/impregnation)between Dren and Brody, and a haunting attack on Polley are featured in SPLICE. The evolution of Dren is quite amazing to behold, and seeing Polley nurturing and raising it with such love and care is particularly heartwrenching once she begins to change into a more malevolent creature.