The song charted on the US Billboard Hot 100, Australia, and the United Kingdom.
"Right Thru Me" is described as being a Electronic, hip hop, R&B, track, compared to her usual rap and features electronic beats and synths.
The music video was shot over the weekend of October 1, 2010 and was directed by Diane Martel and was later premiered on October 27.
Minaj has promoted the song in several live appearances on The Wendy Williams Show, Late Show with David Letterman, Live with Regis and Kelly, Saturday Night Live, and 106 & Park.
The main accompanying melody and chord progression are sampled from the Joe Satriani song "Always with Me, Always with You" from his breakthrough 1987 album Surfing With the Alien.