One of the customers who comes to Jonah to purchase a rifle mentions he just got fired from his job. This is the plot of Falling Down (1993), starring Michael Douglas. The customer is wearing the same outfit Douglas wears in the movie.
Chris Farley's brother Kevin plays the customer in the red shirt and camouflage pants at the gun counter.
The name of the episode refers to the Pulitzer Prize-winning non-fiction book Guns, Germs and Steel: The Fates of Human Societies.
Amy wears a different name tag in each episode. This episode her name tag says "Rachel".
At the end of every episode the card for the production company Spitzer Holding Company features a variety of items they specialize in. In this episode they list Asset Disposal, Museums, and Youth Chiropractics.