Although she had been mentioned previously throughout the show, this is the first episode featuring Louis' sister, Esther. Amy Acker plays the character Esther Edelstein.
The title " No Puedo Hacerlo" translates to: "I can't do it."
Gina Torres and Amy Acker also star in the Buffy the Vampire Slayer (1997) spin-off show, Angel (1999).