When introducing this version of Mr. Freeze, his real name is referred to as Victor Fries and is pronounced with a Dutch inflection, to rhyme with Mice rather than Freeze.
When Victor Fries leaves the drug store after being rejected on the prescription refill, he says, "I'll be back". A slight nod to Arnold Schwarzenegger, who played Mr. Freeze in Batman & Robin (1997). One of Arnold's trademark quotes is "I'll be back" from the Terminator series.
BD Wong (Hugo Strange, head of psychiatry at Arkham) is known for playing therapists, including Dr. Gabriel Lin in NCIS: New Orleans (2014), Dr. John Lee in Awake (2012) and Dr. George Huang in Law & Order: Special Victims Unit (1999).
Supercooled liquid helium, is one of the most effective substances in the world for rapid temperature reduction as opposed to liquid nitrogen which would take significantly longer , depending on mass - and body fat, of course. Supercooled refers to the concept that a substance can remain a liquid even if the temperature drops below the intrinsic freezing point of said substance.
Cobblepot's Arkham number is B-113. This may be a partial reference to a California Institute of Arts classroom (A113) that is repeatedly referenced in animated productions, most famously Wall-E(2008).