In a fun shout out to fans, Sam Anderson appears as Booth's nemesis Hugo Sanderson - echoing his role as Angel's nemesis Holland Manners in David Boreanaz's first hit show.
David Boreanaz and Rance Howard (Jerold Norsky) have worked together before in Carpe Noctem (2001) in which their characters magically swap bodies.
Sam Anderson and T.J. Thyne both guest-starred in the Friends episode The One Hundredth as Phoebe's obstetrician who is obsessed with Fonzie and her short-lived replacement obstetrician whom she yells at, respectfully. This was one of Thyne's earliest acting roles.