Ashburn's yearbook is Sandra Bullock's actual 1982 yearbook from Washington-Lee High School in Arlington, Virginia. The art department digitally manipulated Bullock's picture to include glasses and braces, neither of which she had in her original high school senior portrait. They also took out all the signatures within the book.
Husband and wife actors Ben Falcone and Melissa McCarthy have appeared in several movies together including: The Nines (2007), Bridesmaids (2011), Identity Thief (2013), The Heat (2013), Tammy (2014), Spy (2015) and The Boss (2016).
In the version shown in Lithuania, the classic "Balls" scene is dubbed to "brains." It worked fine until she says, "Little girl brains, if little girls had brains."
The voice of the neighbor who's calling for her cat to come back from Ashburn's apartment is Melissa McCarthy (uncredited).
According to writer in a Huffington Post article, Katie Dippold, Sandra Bullock and Melissa McCarthy were looking to make a movie together before they found the script for The Heat (2013).