In this episode Liz's mother mentions graduating secretary school and going to work for Sterling Cooper. Sterling Cooper is a fictional ad agency from the show Mad Men (2007-2015), which stars 30 Rock guest star Jon Hamm.
While Tina Fey was head writer of Saturday Night Live (1975), she oversaw and participated in a Mother's Day episode that featured cast members' mothers, including her own.
The Mother's Day episode of "TGS" ends with the mothers each singing a piece of a cheerful song. At least two of the mothers are played by actresses who are primarily famous for their roles in Broadway musicals - Elaine Stritch, who plays Colleen (Jack's mom) and Patti LuPone, who plays Sylvia Rossitano (Frank's mom). LuPone deliberately sang her character's line off-key, even though she has won two Tony awards for musical theater performances (and been nominated for another three).
In Liz's mom's flashback she is played by Tina Fey and her boyfriend (astronaut Buzz Aldrin) is played by the same actor that plays the made up astronaut (Mike Dexter) Liz always fantasizes about.
Matthew Weiner and Jack Burditt are listed as the writers of "Bitch Hunter". Burditt is a writer for 30 Rock (2006) and Weiner is the creator of Mad Men (2007), a show which features former guest-star Jon Hamm in the leading role and is referenced during this episode.