Rutger Hauer lost his balance and fell when climbing out of the shopping cart. Director Jason Eisener decided to keep it in the movie.
Professional wrestler Jake "The Snake" Roberts was the first person considered for the role of Drake.
The actor from the original Grindhouse (2007) trailer, David Brunt, was supposed to play the lead character. However, he disappeared for weeks. When he was eventually found, he admitted that he had purposely disappeared as he was too fearful of carrying a film by himself. The producers consoled him with a cameo role instead.