The group from the original series meets at The Max for a tribute to Screech. Screech's robot Kevin also makes an appearance. They imply that Screech has passed but do not state that he has died.
After Dustin Diamond (Screech Powers) died from lung cancer in February 2021, series EP Tracey Wigfield worked to create a script that would pay homage to both Diamond and his fictional counterpart. She flew in Diamond's close friend Dan Block to meet with her and the other producers and hear stories that were used to craft the S2 premiere. While it's never clearly stated how Screech died, or even that he actually passed away, the episode provides several hints that this is what happened before the heartfelt ending, where the original cast gathers at the Max to pay tribute to their late friend.