At the beginning of the episode when Thirteen examines Spencer for a spider bite, no body double is used. Angela Gots appeared fully nude, which surprised Olivia Wilde.
House says, "It was either this or put on Brian's Song," referring to the 1971 ABC TV movie telling the true-life story of how two Chicago Bears football players bonded despite the competition for the same position and their racial differences, and how they deal with one dying of cancer.