- Dr. Meredith Grey: Every surgeon has a shadow. And the only way to get rid of a shadow, is to turn off the light. To stop running from the darkness, and face what you fear. Head on.
- Dr. Meredith Grey: Every surgeon I know has a shadow. A dark cloud of fear and doubts that follows even the best of us into the or.
- Dr. Meredith Grey: Every surgeon has a shadow. And the only way to get rid of a shadow is to turn off the light. To stop running from the darkness, and face what you fear. Head on.
- Adele Webber: [to Richard] Out of all the petty, ridiculous, infantile... are you running a hospital here or a playground?
- Dr. Richard Webber: Adele, I won't be spoken to in that...
- Adele Webber: Hospital or playground, Richard?
- Dr. Richard Webber: [sighs] Hospital.
- Adele Webber: Well, then start acting like the Chief of a hospital and
- [motions to Bailey]
- Adele Webber: apologize to that woman right now.
- Dr. Richard Webber: [mutters] Sorry.
- Adele Webber: You call that an apology? Now you better not leave this room until the two of you have worked this out because if I have to drag myself down here through rush hour traffic again, to police this damn jungle gym...
- Dr. Richard Webber: Adele, you've made your point.
- [Adele is about to leave and she sees Bailey with a huge smirk on her face]
- Adele Webber: [to Bailey] And you wipe that smile off your face, you're no better. Tattling on a man to his wife.
- Dr. Izzie Stevens: You think every time you diagnose a patient and hand someone a death sentence, there's a prize? The prize is, you didn't screw it up this time. The prize is, you people actually did something right. The prize is, you were doctors today. You were doctors. That is the prize!
- Dr. Izzie Stevens: [to Lexie] What would you say? To Patient X. How would you... How would you break the news?
- Dr. Lexie Grey: Um, I would say that I was very sorry, and that there were support groups. Th... I... I don't know. What do you say to somebody whose, whose gonna...
- Dr. Izzie Stevens: You say, they have a choice. They can run away and hide from it, or they can face it. You say they need to be around the people who love them, because it's gonna be the toughest fight of their life, and no one should have to do it alone. And then you give them the odds. And even though a 5 percent survival rate is bad, it's really bad. You say... you say...
- Dr. Lexie Grey: Screw the odds! People die of the hiccups. My mother died of the hiccups. Survival rate for that is what... 100 percent? The odds are that she should be alive right now. The odds are... The odds mean crap! So people should face it and they should fight. Maybe not those words.
- Dr. Izzie Stevens: No. Exactly those words. Thank you, Dr. Grey.
- Dr. Lexie Grey: Yes, the odds are against us. I'm a one woman wrecking ball, all I do is break you. Your hand, your penis, your relationships, your life. I'd say our survival rate is about 3 percent. And that's... that's, that's bad. But, it's not nothing and I don't think we should give up on this. At least not yet because...
- [Mark puts a finger to Lexi's lips to stop her from talking]
- Dr. Lexie Grey: Okay.
- Dr. Mark Sloan: You think you broke me Little Grey? You're the one that put me back together.
- [Lexie smiles]
- Dr. Meredith Grey: What's this "Patient X" thing that's taking all the interns?
- Dr. Cristina Yang: When's it going to be over? I need minions to do all my crap work.
- Dr. Alex Karev: It's some new teaching thing.
- Dr. Cristina Yang: We're all killing ourselves to get into the OR. When's the last time Izzie held a scalpel? She's falling behind. She's like the new O'Malley.
- Dr. Alex Karev: Izzie's nothing like O'Malley.
- Dr. George O'Malley: Hello.
- Dr. Izzie Stevens: Maybe Cristina's right. Maybe trying to teach the interns is pointless.
- Dr. George O'Malley: Please. Don't listen to Cristina. She thinks just because you'd rather teach than take out a gall bladder, that you're the new me.
- Dr. Izzie Stevens: [laughs] O'Malley, the sequel.
- Dr. George O'Malley: [laughs] O'Malley 2.0.
- Dr. Meredith Grey: [to Derek] You cleaned all of your clothes out of the closet at the house.
- Dr. Derek Shepherd: Go home, Mer. Just go home.
- Dr. Meredith Grey: Well, how long are you planning on hiding out here? Because that's what you're doing. You're hiding. You made a mistake, she's dead and you can't hide from that.
- Dr. Derek Shepherd: I'm not hiding. I'm done. I'm done operating.
- [starts hitting empty beer cans with a baseball bat]
- Dr. Meredith Grey: Oh, okay. So you're just quitting?
- Dr. Derek Shepherd: You should understand better than anybody else. You wrote the book on quitting, running, hiding. You've written a lot of books, Meredith.
- Dr. Cristina Yang: Hunt won't even look at me since he went all "Apocalypse Now" on me this morning.
- Dr. Meredith Grey: [to Derek] How'd it go with the lawyers?
- Dr. Derek Shepherd: They told me my death rate.
- [looks at the small pile of files]
- Dr. Derek Shepherd: These are the people I saved.
- [looks at the big pile of files]
- Dr. Derek Shepherd: These are the people I killed.
- Dr. Meredith Grey: Okay. Well, most of those people were terminal when they came to you. You were their last chance and you take on impossible cases. Look at the clinical trial.
- Dr. Derek Shepherd: It's just so many people. More than Dahmer, Mason, and Bundy combined.
- Dr. Meredith Grey: You're not looking at the big picture.
- Dr. Derek Shepherd: [points to the big stack of files] This is the big picture.
- Dr. Alex Karev: [about Derek] Dude, he's fried.
- Dr. Meredith Grey: He is not fried. He lost a patient and got hit with a lawsuit all in the all in one week. He just needs time.
- Dr. Alex Karev: He's been sitting there for three days. The sofa cushions are gonna start bonding to his ass and he's eating all of my cereal.
- Dr. Izzie Stevens: He's taking stock. Something huge and life-altering happened to him and he's taking stock, figuring out his next move. We shouldn't judge him. We shoudn't rush him.
- Dr. Alex Karev: Whatever. Sylvia Plath's picking out all of the marshmallows. They're the best part!