This is an early Mutt and Jeff cartoon. Based on the characters created by the cartoonist, Bud Fisher, the pair of characters appeared in 1907 and continued until 1983--with various artists illustrating them. While Fisher told the world he made the cartoons himself and his name appears prominently on the title cards, according to Leonard Maltin's history of animation, Fisher actually left these silent cartoons up to others to make.
I've seen several of the Mutt and Jeff cartoons and compared to them, "Domestic Difficulties" seemed a bit stiffer and more poorly animated. But, considering how early these cartoons were, I tend to cut them some slack.
The cartoon finds Mutt at home and his wife is going out---so Mutt sneaks off to the bar with Jeff. Unfortunately, they get so drunk that they don't come back until 3am---and wow, is Mutt's wife mad! In many ways, the plot is much like a Laurel & Hardy film or episode of "The Honeymooners" or "The Flintstones" and "Domestic Difficulties" is one of the earliest films with such domestic entanglements. Worth seeing though far from the best in the series.
Oddly, I found this cartoon as an extra in the Popeye multi-disc set!