In House's initial differential diagnosis, the hospital custodian submits that the patient may have lupus. This causes House to take an extra long pause. Incorrectly suggesting lupus as an underlying condition is a running gag on the show.
Because this episode centers on an office catastrophe, as a play on the show that was also popular at the same time, The Office (2005), a few scenes are shot in the same style.
Although Jesse Spencer, Omar Epps, and Jennifer Morrison can be seen in the opening credits, none of them appear in this episode.
House asks, "Am I in an M. Night Shyamalan movie?" referencing the director responsible for primarily supernatural movies such as The Sixth Sense (1999), Unbreakable (2000), Signs (2002), The Village (2004), and Lady in the Water (2006).