The makers unsuccessfully approached famous Hollywood actors Morgan Freeman, Robert De Niro and Al Pacino for doing a key role in the film. Later actor James Cosmo was signed on to play the concerned role.
Dhanush was reportedly unhappy with producer Sashikanth's decision to go for a direct digital release instead of a theatrical release, despite the fact that cinemas were already being reopened during the COVID-19 pandemic.
Dhanush has stated that Jagame Thandhiram (2021) was one of the quickest films in his career, as filming was completed within four months.
When Suruli first sees Atilla in the pub, he remarks that she is gorgeous, so she must be a Tamil girl. This is ironic since Aishwarya Lekshmi is actually a Malayalam actress.
The digital rights of this film were sold for US$7.7 million, thus making it the highest-paid Tamil film to get a direct digital release.