Bizarro's skin is only distorted when exposed to direct sunlight. In the comics, his skin is irreversibly distorted.
Kara is first seen dressed nearly the same way as Raya was when she resided in the Phantom Zone.
This is the first season premiere that doesn't feature Martha Kent.
In the comics, Bizarro has a crush on Lois Lane. In this episode, he also unsuccessfully flirts with her.