Paul Bettany and Jennifer Connelly, who portray Charles Darwin and his wife, are married in real life.
Harbour scenes were filmed in Charlestown, St. Austell, Cornwall, UK, the same area used by Tim Burton a few weeks earlier for Alice in Wonderland (2010). The same extras casting agency was used for both.
Anne Elizabeth "Annie" Darwin's death (2nd March, 1841 - 23rd April, 1851) may have been caused by scarlet fever, or tuberculosis as some may believe.
It is often thought that apart from his illnesses, Charles Darwin may too have had Ménière's disease.