Maria and Tony are the names of the leads in "West Side Story," which, like this episode, is based on Romeo and Juliet
The title is based upon a quote from William Shakespeare's play "Romeo and Juliet": (Act II, Scene II): "O Romeo, Romeo! Wherefore art thou Romeo?"
This is the second time Victreebel eats someone else's head besides James upon being released. The first victim was Meowth five episodes earlier.
At the end of the episode, Team Rocket breaks the fourth wall, replying to the narrator's comment.
Misty references England, a real-world location, at the beginning of the episode.