Wolverine refers to Bishop as "ol scarface" during the anti-mutant mob attack. The "M" on Bishops face is actually a tattoo to identify him as a mutant in the future.
The robots Cable is fighting in the future resemble the T-800 from the Terminator movies. It also sees everything in the color red with a computer readout on its HUD.
Cameos: Scaleface & Mole (the hairy mutant with no powers as seen in a previous episode but his name is never mentioned) in the quarantined building.
Debut: Clan Chosen (The people fighting with Cable in the year 3999): Hope, Dawnsilk, Boak & Kane.
The hospital patient list is made up of crew members or their families: Alexandra Fierro, Frank Squillace, Emmitt Houston, Lucille Brown, Angel Pollard, Adrian Houston (who's supposed to be the infected Store Clerk from "Emmitt's Electronics Store"), Mark Lewis, Brendan Thomas, Larry Houston, Greg Garcia, Joe Brown, and "Babes" Battle.