This episode features the final appearances of Cable, Bishop, Shard, Archangel, Psylocke, and the Nasty Boys in the show.
One of the telepaths that Apocalypse captures bears a strong striking resemblance to Guardian of The Universe member Ganthet of Oa. From DC Comics Green Lantern series.
Mojo and the Savage Land can be glimpsed in time portals as Apocalypse is erasing time and space
As Sinister and the Nasty Boys are retreating through a time portal, Gorgeous George can be seen getting hit by one of Cable's laser blasts, indicating he may have been killed.
Rachel Summers, Mastermind, and Moondragon can be seen in Apocalypse's collection of psychics.