The second female pedestrian featured in the opening credits is series creator and writer Diane English making a cameo.
The title is from the 1974 song "The Bitch is Back" by Elton John and Bernie Taupin reaching #4 on the charts in the U.S.A.
While in the hospital Murphy is greeted by Dr. Bishop, played by David Paymer, who tells her she can "forget about leading that cattle drive". Around the same time, the movie "City Slickers" (in which Paymer had a role) was being filmed. The movie was about a group of people participating in a cattle drive.