It's bright and sunny when Hulk leaves South Dakota, but night moments later in Detroit. The time difference is not so great between these two places.
The homeless man is brought in with his clothes. When he is taken to Donald Blake he is shirtless and hatless. When he attacks Betty Ross he is full clothed again.
Donald Blake turned into Thor in a hazmat suit, but changes back into a business suit.
The hazmat suits have mittens for gloves. It's not very effective for the careful delicate handling of patients and equipment. Real hazmat suits have fingered gloves.
Abomination could not have left his footprints nor salt since he had the special harness on his feet too.
There are six sides to a cube, but eight squares are released from the helicopter for the rage cage. It's possible that two were just for back up.
When Bruce Banner and Donald Blake stand in the hallway, a woman walks through a door and her arm phases through it.
The area around Mount Rushmore is nothing like in real life. For example, there are no trees on top and the mountain stretches up higher than the presidential faces.