- Continuity: The logos on top of the HSBC and Citigroup buildings vary from nonexistent to clearly visible.
- Revealing mistakes: About halfway into the movie, the "infected" charge frantically down the dark tunnel. When they reach the stairs, they all slow down, take small steps, and grab the side rails to avoid falling.
- Continuity: When the girl is in the pizza shop, a window above the Greek restaurant is alternately open and shut in different shots.
- Errors in geography: When the aircraft with repatriated people approaches London, it is headed to Runway 28 at London City Airport. When the passengers get off the aircraft, they are at Stansted Airport, in the terminal buildings.
- Errors in geography: The route the survivors took around London, and the distances involved, would not be possible in the time frame as shown in the film.
- Continuity: When the survivors are driving to escape the toxic gas, the windshield is covered in blood, which disappears in the next shot, then reappears.
- Continuity: Flynn's helicopter changes multiple times. He falls asleep in an Aerospatiale Gazelle. When he attempts to rescue Doyle, he is flying an Aerospatiale A-Star. When he lands in the stadium to rescue Doyle and the children, he is once again flying an Aerospatiale Gazelle.
- Continuity: At the end, when the helicopter approaches the cliffs of Dover, all the fields have short, neat grass. After 6 months without mowing, they should be wildly overgrown.
- Factual errors: Scarlet wears her hair in a ponytail while in uniform. The US Army requires females in uniform to wear their hair above their collar.
- Errors in geography: The DLR train carrying the settlers from the airport has "Greenwich" on the front. Greenwich is across the river from Isle of Dogs, so it wouldn't have been quarantined.
- Factual errors: At Charing Cross station, during Don and Scarlet's showdown, a Jubilee Line train is on the platform. The Jubilee Line hasn't stopped at Charing Cross since 1999.
- Factual errors: In the surgery scenes, people are only wearing surgical masks. The virus is transferred via blood and body fluids, so everyone in quarantine should have worn goggles, especially the doctor.
- Revealing mistakes: When Don is running across the field from the farmhouse to the boat jetty, you can see fresh tire marks in the grass from earlier takes.
- Continuity: When Andy is jumping on the trampoline, the grass is trimmed. After 6 months of neglect, the grass would be overgrown, and the trampoline covered in debris.
- Factual errors: After repeated attempts to start the car using the starter, Doyle decides to push-start the car to help Andy, Scarlet and Tammy escape the gas. Push-starting only works when the battery doesn't have enough power to activate the starter. Since the starter was working, push-starting would be useless.
- Revealing mistakes: When the children are riding the motorbike through the cemetery, fresh flowers are on one of the graves. Since the cemetery is outside the quarantine zone, there should be no-one around to visit the deceased.
- Audio/visual unsynchronized: Many times, the actual sounds of the Aerospatiale Gazelle are replaced by a more familiar helicopter sound, although in a few places, you do hear the Gazelle's distinctive high rotor speed and squealing from the Fenestron tail rotor.
- Crew or equipment visible: When Flynn is hovering next to Doyle, you can clearly see the stunt pilot, wearing a black balaclava, glasses, and a radio headset.
- Errors made by characters (possibly deliberate errors by the filmmakers): General Stone says that the Infection does not "cross species." However, the original outbreak began when humans came in contact with infected chimps. This is most likely caused by a confusion between Order and Species. The Rage virus can infect all species within the primate order, but it cannot infect any other order (aquatic life forms for example).
- Factual errors: Flynn's helicopter is a British Gazelle. The US force could have taken control of it after arriving, but considering the state of the country, and the fact that the US uses their own equipment when possible, it's not likely.
- Miscellaneous: The tag line on the cover of the DVD reads, "When days turns to weeks... the horror returns." Turns should be turn.
- Revealing mistakes: Doyle tries to start the car using the starter while sitting on the left side of the car. In England, the steering/starter switch is on the right side. When he decides to push-start the car, to help Andy, Scarlet and Tammy escape the gas, Scarlett tries to start and drive from the right side.
- Continuity: (At 12:53) A plane is shown landing at London City Airport. Once the aircraft is on the ground, it is shown (At 13:02) taxing to a gate at London Stansted Airport.
- Errors in geography: (At 13:54) The airport control tower at top left is the one at London Stansted Airport, not London City Airport.
- Revealing mistakes: (At 13:54) two characters are shown getting off a plane via a walkway at London City Airport. This is a shot from a walkway at London Stansted airport, and the position of the control tower in the background reveals that the characters are in walking towards the aircraft, not away from it.
>>> WARNING: Here Be Spoilers <<<
Goofs below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- Revealing mistakes: SPOILER: Infected Don kills Scarlett by beating her with the M4, swinging it like a baseball bat. Viewed through the scope, it looks like he is jabbing her with the muzzle of the gun.
- Revealing mistakes: SPOILER: After code red is called, aircraft come in to firebomb Canary Wharf. They lay down carpets of fire in the streets, but the light from the flames is not reflected in the huge number of windows in the buildings which line these streets.
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