- Revealing mistakes: During the scene in which Tokyo appears, there are several Japanese signs that just have random Japanese ideograms completely irrelevant to what should be there.
- Revealing mistakes: In the scene where they first show the corpses of clones from Project Alice you can clearly tell that a few of them are in actual fact mannequin dolls. Some of the corpses don't have any facial similarities as the real Alice and one of them doesn't even have any hair.
- Crew or equipment visible: When Alice walks through the dunes, just before the crow's attack, the cameraman filming her is visible in her glasses.
- Continuity: The opening scene in which Alice is naked in the shower shows her with no makeup. Yet, upon wearing the red dress she is wearing red lipstick. Then, in subsequent shots she is wearing no lipstick again.
- Errors in geography: After the characters arrive in Las Vegas, they park right next to the Paris Casino's Eiffel Tower and the Venetian Casino. In reality, The Venetian is one mile up Las Vegas Blvd (The Strip).
- Revealing mistakes: In the scene where Alice reads Stevie's name tag, with the help of a magnifying scope, a duplex reticle can be seen. However, right before she shoots him with the crossbow, it can clearly be seen that her crossbow is equipped with an open design type of red dot sights. These devices do not magnify at all and they have a red/amber luminous dot (hence the name) instead of the previously seen duplex reticle.
- Revealing mistakes: In the scenes where Alice and Carlos are standing around the trucks just before Carlos' suicide run on the Umbrella installation, cars on a highway can be seen in the background. At least three or four going in opposite directions. Maybe another Caravan coming FROM Alaska!
- Continuity: While Carlos is crawling under the truck his pistol's slide is forward, however when he tries to fire and we hear clicking, the slide is locked back indicating it is empty.
- Continuity: When the convoy is introduced the lead vehicle is a Hummer. Later a shot is shown of the tanker bursting through a sand dune, which could only happen if it was the lead. Another shot is shown immediately after with the Hummer as the lead again.
- Revealing mistakes: When Claire takes off in the helicopter she uses the cyclic stick and not the collective. Only the collective can be used to take off vertically.
- Continuity: When Alice is first seen with Carlos and K-Mart looking down at the Umbrella HQ's aboveground "camp," we're looking alongside Carlos's shoulder, and he's immediately behind Alice and slightly to her right. Alice looks through the binoculars and speaks to K-Mart, when Carlos is suddenly sitting 20-30 feet away to the right, and a bit further front than the ladies.
- Revealing mistakes: In the scenes in the pit with Alice and the zombie dogs, there are numerous shots where the dogs can be seen to still have furry, non-zombified tails.
- Factual errors: Despite having driven through the sandy desert for many miles, Alice's motorbike is repeatedly shown to be very clean and dust-free.
- Continuity: The zombies in the series have previously been shown to have considerably greater strength than a normal person yet the hundreds surrounding the Umbrella Corporation's desert outpost are very effectively halted by a ten foot high chain-link fence.
- Factual errors: Despite the depth of LJ's chest wound after his encounter with the zombies at the motel, he appears to be in no discomfort, nor is there anywhere near sufficient blood on his chest and t-shirt for that kind of wound.
- Factual errors: None of the Alices in the ditch show any signs of decomposition and all look to be very recently killed - their skin isn't even paled from blood pooling in the lower tissues, something that occurs within hours of death.
- Revealing mistakes: When Oded Fehr's character is saying goodbye to everyone at the end and Ali Larter's character is looking at him, you can clearly see traffic moving on the road in the background.
- Incorrectly regarded as goofs: After Alice uses her powers to kill the crows, Dr. Isaacs uses 3 satellites to locate her - as evidenced by the display on his computer monitor. Three smaller circles, presumably satellites, centered around a larger circle, presumably the radius of her psionic ability - even though we only see one satellite in orbit. Even if the satellites are not sensitive to psionic bursts (though they should be, since the AI in the Umbrella facility claims to have detected them), Project Alice has several implants which allow Umbrella to track and control her.
- Incorrectly regarded as goofs: In the council chambers, Wesker's glasses reflect the room around him. This isn't a mistake - all council chambers are identical, and Wesker's holographic cameras would pick up the reflection of his table - as well as the reflections of the other holograms in the room during a meeting.
- Continuity: During the Vegas scene, the laptop in the Umbrella tent is locked on to Alice, yet there's a display box containing Africa in the lower left corner. There would be no logical reason for the Umbrella operatives to keep a look out on Africa when they're busy with Nevada.
- Revealing mistakes: At the start of the final scene in Tokyo, there are rats in the street. As the camera descends through the street, one of the rats actually goes in front of the ground revealing that the street is actually a cut-away set.
- Revealing mistakes: When Dr. Isaacs is held in a "secure room" the keypad used to release the door is quite clearly that of a cheap digital safe (the sort one would buy for keeping a few household valuables) and no attempt has been made to conceal the circular handle of the safe, the rest of which has been built into the wall.
- Revealing mistakes: When the zombies are coming out of the large container, there are tons of them coming out of it but there's no way they could have all fit into the container in the first place.
- Plot holes: Alice notes that instead of driving to Alaska, they will fly there. So when they breach the gates of the Umbrella compound, they all load up into the helicopter and take off. Claire is the pilot, however, it is never mentioned in the movie that she, nor anyone else, has experience flying. Flying a helicopter is not the same as driving a Hummer.
- Continuity: During the crow scene when the flamethrower is about to incinerate Carlos, the woman he is holding has her hand on his shoulder. When we cut to Alice in the next shot we can see the woman's hand slide down off of Carlos' shoulder and then reappear there in the next shot.
- Continuity: Towards the end when Alice enters the Umbrella HQ and releases a clone of herself from the water/orb, the clone then dies. She is shown laying on the ground with her left hand covering only her left breast, with her elbow resting on the floor. In the next shot, from above, her arm is covering both and her elbow is no longer resting on the ground.
- Continuity: In the beginning of the movie, the first Alice clone is in a laser chamber where the pattern of the lasers that charge after her are diamond, but then a shot later when she climbs through an air duct, the laser pattern is just a straight line.
- Continuity: The first Alice clone is killed by a small gun thing that shoots up out of the Umbrella logo floor where bullet holes are left around the walls. Later on when another Alice clone has to go through the same obstacle course, those bullet holes that were left behind from the first Alice clone are missing.
- Continuity: The first Alice clone pushes a gurney through the hospital hallway where a blade wall slices the gurney in half, then two shots later, the blade trap is completely gone.
>>> WARNING: Here Be Spoilers <<<
Goofs below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- Continuity: SPOILER: When the first Alice clone awakens and attempts to leave the underground compound, flashbacks guide her in avoiding fatal danger. During the hospital hallway scene where she pushes a bed with wheels, a guillotine comes down the walls and slices the bed in half. The walls clearly show the gap where the guillotine comes out from but on the next frontal scene, the walls are bare.
- Revealing mistakes: SPOILER: In the scene where Carlos is in the big rig lighting up his joint, the camera pulls back and you can clearly see that one of the zombies reaching in for him only has makeup just past his wrist where you can then see normal human skin between that and the sleeve of his clothing.
- Continuity: SPOILER: In the scene where Dr. Isaacs as the tyrant has Alice in a choke hold, she clearly cuts off the ends of his fingers. Yet moments later, we see a shot of her and the floor, but his large fingers are not visible on the ground where they should be.
- Continuity: SPOILER: When the bus gets attacked by the crows Ashanti's character Nurse Betty has blood and dirt on her face. But after she locks the back door and she shoots the crows she is clean and there is no blood or dirt on her, then in the next shot when she dies she is bloody again.
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