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"Grey's Anatomy" (2005) More at IMDbPro »
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Season 1
Season 1, Episode 1: A Hard Day's Night
27 March 2005Meet Meredith Grey. Daughter of famous surgeon Ellis Grey and currently a first year intern at Seattle Grace Hospital. On her first day, she meets her fellow interns: Cristina Yang, a highly competitive Stanford graduate. George O'Malley, a quirky yet warm hearted guy. Izzie Stevens, a former model who's always optimistic. Overseeing them is Miranda Bailey, dubbed by her coworkers "The Nazi". Meredith also gets a surprise when she realizes that her one night stand from the night before is her new boss.
Season 1, Episode 2: The First Cut Is the Deepest
3 April 2005The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile, Meredith puts her career on the line to save a newborn in the hospital nursery, and the other interns learn that it takes more than just medical knowledge to be good at their jobs.
Season 1, Episode 3: Winning a Battle, Losing the War
10 April 2005A bike race injures several people, one of whom is left brain dead. Cristina and Izzie want to use his organs for organ donation, but they find the organ harvesting process an emotional one. Meanwhile, George deals with an over-flirtatious patient, and Meredith has to deal with Izzie and George moving in, Alex showing off, and keeping Derek at arm's length.
 | Ellen Pompeo | ... | Dr. Meredith Grey |
 | Sandra Oh | ... | Dr. Cristina Yang |
 | Katherine Heigl | ... | Dr. Izzie Stevens |
 | Justin Chambers | ... | Dr. Alex Karev |
 | T.R. Knight | ... | Dr. George O'Malley |
 | Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
 | Isaiah Washington | ... | Dr. Preston Burke |
 | Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Keith David | ... | Lloyd Mackie |
 | Callum Blue | ... | Viper |
 | Claire Lautier | ... | Shelley Davidson |
 | Steven W. Bailey | ... | Jeremy |
 | Kathleen M. Darcy | ... | Anesthesiologist |
 | Zina Zaflow | ... | Nurse |
| Dinah Lee | ... | Grungy Chick |
| Rudolph McCollum | ... | Viper's Male Friend |
| Kelsey Kemper | ... | Shelley's Daughter |
| Kristy Munden | ... | Nurse #2 (as Kristy L. Munden) |
Season 1, Episode 4: No Man's Land
17 April 2005Alex uses Izzie's modeling against her, and her last ad causes a patient to reject her care. Meredith finds parallels between a patient and her mother, and Christina must deal with a hospital-savvy patient.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Anna Maria Horsford | ... | Liz Fallon |
 | F.J. Rio | ... | Jorge Cruz |
 | Valerie Cruz | ... | Zona Cruz |
 | Taylor Nichols | ... | Rick Humphrey |
| Kate Burton | ... | Ellis Grey |
 | Tom Choi | ... | Fluoroscope Tech |
 | Chris Hendrie | ... | Dr. Harry Victor |
| Moe Irvin | ... | Nurse Tyler Christian |
| Helene McCardle | ... | ER Doc (as Helen McCardle) |
 | Jack Merrill | ... | Radiology Tech #2 |
 | John O'Brien | ... | Radiology Tech #1 |
Season 1, Episode 5: Shake Your Groove Thing
24 April 2005Meredith realizes that she must take on a lot more responsibility when she is told that her mother needs to sign over all of her assets to her. Izzie prepares to have a party for her boyfriend Hank's visit, but the size of the party far exceeds her expectations. Meredith has her first heart surgery, during which she fears that she has accidentally damaged the patient's heart. Meanwhile, Cristina and Burke hit it off.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Brent Sexton | ... | Jerry Frost |
 | Jonathan Scarfe | ... | Hank |
| Kathryn Joosten | ... | Stephanie Drake |
| Barry Shabaka Henley | ... | Mr. Patterson |
| Kate Burton | ... | Ellis Grey |
 | Jeff Doucette | ... | Warren Sterman |
| Steven W. Bailey | ... | Anesthesiologist Jeremy |
 | Kate Forster | ... | Jane Richie |
| Moe Irvin | ... | Nurse Tyler Christian |
| Jane Morris | ... | Ms. Goff |
 | Andre Panossian | ... | Perfusionist |
Season 1, Episode 6: If Tomorrow Never Comes
1 May 2005All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced that the woman's prognosis is not good. Now that Bailey knows about Meredith and Derek's affair, their jobs are in jeopardy, and she strongly advises Meredith to end it. Meanwhile, Cristina and Burke's secret relationship gets more complicated, and when no one else can be reached, Izzie has to perform a major procedure on her own.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber (credit only) |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Bruce Weitz | ... | Edward Levangie |
 | Alex Alexander | ... | Annie Connors (as Alex S. Alexander) |
| Jane Galloway Heitz | ... | Annie's Mom |
 | Lara Phillips | ... | Mary Levangie |
| Steven W. Bailey | ... | Anesthesiologist |
| Sean Palmer | ... | Intern |
 | Patricia Bethune | ... | Nurse Ginger |
 | Yvonne Farrow | ... | Heart Patient's Wife |
| John O'Brien | ... | CT Tech |
| Yolanda Snowball | ... | Physical Therapist |
 | Walter Wong | ... | Echo Tech |
| Moe Irvin | ... | Nurse Tyler Christian |
 | Noelle McCutchen | ... | Nurse Vivian |
 | Sharmila Devar | ... | Female Intern |
Season 1, Episode 7: The Self-Destruct Button
8 May 2005Derek and Meredith try to be discreet as they spend the night together at Meredith's house, but their haggard appearance speaks volumes to Bailey, who warns Meredith to end the relationship. Meanwhile, George suspects an anesthesiologist of drinking on the job, Alex treats a former competitor who now finds honor in self-mutilation, Izzie has to deal with a patient who won't let his girlfriend go, literally, and Cristina battles a case of what seems to be the flu.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber (credit only) |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Ever Carradine | ... | Athena |
| Russell Hornsby | ... | Digby Owens |
 | Amanda MacDonald | ... | Claire Rice |
 | Kim Morgan Greene | ... | Tina Rice |
 | Sarah Utterback | ... | Nurse Olivia Harper |
 | Joseph Kell | ... | Mr. Rice |
| Regan Forman | ... | Gwen Hayes |
 | Bill Birch | ... | J.P. |
 | Larry Cahn | ... | Dr. Taylor |
 | Doug Sinclair | ... | Brett Hayes |
 | Steve Monroe | ... | Orderly |
 | Shenita Moore | ... | Surgical Nurse |
| Vanessa Rogers | ... | Jamie Hayes |
| Rebecca Rogers | ... | Jamie Hayes |
Season 1, Episode 8: Save Me
15 May 2005Meredith grows increasingly dissatisfied with fact that she knows nothing about Derek's life. Meanwhile, Alex treats a patient whose religious beliefs jeopardize her chances for recovery, and Izzie contemplates reconnecting with her estranged mother. Also, a pregnant woman in her 40s who's been diagnosed with cancer disagrees with Cristina's medical advice. And the interns are mystified by a patient who's being treated for seizures and who thinks he's psychic.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber (credit only) |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Joan McMurtrey | ... | Zoey Glass |
 | Kevin Rahm | ... | Mr. Duff |
 | Josh Stamberg | ... | Tommy Walker |
 | Sarah Hagan | ... | Devo Friedman |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Ping Wu | ... | Seymour Glass |
| Charles Walker | ... | Dr. Chesney |
 | Chad Einbinder | ... | Sam Friedman |
 | Lisa Kaminir | ... | Doris Friedman |
| Steven W. Bailey | ... | Joe |
| Kathleen Bailey | ... | Reproductive Counselor |
 | Darlene Kegan | ... | Ruby Walker |
 | Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 1, Episode 9: Who's Zoomin' Who?
22 May 2005A sexually transmitted disease breaks out and affects several members of the hospital staff. Meanwhile, Webber reluctantly tells Derek about his own medical concerns. Izzie and Cristina worry about a patient's wife and daughter who can't agree on his care. Burke treats his college buddy Bill, whose medical diagnosis raises some questions regarding his wife's actions. And just as Meredith and Derek grow more intimate, a surprise from his past shows up.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Lauren Bowles | ... | Alice Franklin |
 | Wendy Davis | ... | Holly Adams |
 | Wayne Wilderson | ... | Bill Adams |
 | Catherine Dao | ... | Dr. Knox |
| Joyce Guy | ... | Ms. Henry |
 | Patty McCormack | ... | Rebecca Franklin |
| Jack Merrill | ... | Lab Tech |
| Robin Pearson Rose | ... | Patricia |
 | Jack Shearer | ... | Jordan Franklin |
| Sarah Utterback | ... | Nurse Olivia Harper |
Season 2
Season 2, Episode 1: Raindrops Keep Falling on My Head
25 September 2005Meredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
Season 2, Episode 2: Enough Is Enough
2 October 2005After a fatal car accident, a man, a woman and their son are patients in the Seattle Grace hospital. The injuries of the mother reveal a family secret. Another patient has swallowed something strange, but refuses to reveal what. On the personnel level, Meredith and Cristina try to get along with the ending of their relationships. While Meredith tries to avoid Shepherd, Cristina and Burke are involved in the same medical cases. George feels uncomfortable still working with Olivia, who wants him to forgive her. Derek also reveals why he left New York.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Loretta Devine | ... | Adele Webber |
 | Scott Michael Campbell | ... | Mr. Hubble |
 | Romy Rosemont | ... | Lea Seibert |
 | Lukas Behnken | ... | Scott Seibert |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Robin Pearson Rose | ... | Patricia |
 | Jim Gleason | ... | Dr. Domner |
 | Peter Birkenhead | ... | Dr. Orsen |
 | Yvette Cruise | ... | Scrub Nurse |
 | Jeremy Rabb | ... | ER Resident |
 | David Haley | ... | Paramedic #2 |
| Linda Klein | ... | Nurse Linda |
 | Seth Adams | ... | Radiologist |
 | Johanna McKay | ... | Grieving Widow |
| John Cappon | ... | Paramedic #1 |
| Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 2, Episode 3: Make Me Lose Control
9 October 2005Meredith's mother is admitted to the hospital, revealing that the once great surgeon now has Alzheimer's disease. Menwhile, Christina faints during operation and needs immediate care. She loses her baby due to complications and becomes a patient. Burke finally finds out about her pregnancy when it's too late. Mrs Grey gives hell to George because she thinks he is her husband, but George copes with it.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Angela Goethals | ... | Kelly Roesch |
| Kate Burton | ... | Ellis Grey |
| John O'Brien | ... | Lab Tech |
| Brian Breithaupt | ... | Mr. Gaston |
| Linda Klein | ... | Nurse Linda |
| Noelle McCutchen | ... | Nurse Vivian |
| Jeremy Rabb | ... | ER Resident |
Season 2, Episode 4: Deny, Deny, Deny
16 October 2005Christina becomes a patient and Meredith deals with her mother's illness.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Thomas Ian Nicholas | ... | Jeremiah Tate |
 | Don McManus | ... | Samuel Linden |
| Tsai Chin | ... | Helen Rubenstein |
 | Lee Garlington | ... | Fara Linden |
| Katherine LaNasa | ... | Vera Kalpana |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Moe Irvin | ... | Nurse Tyler Christian |
| Kathleen M. Darcy | ... | Anesthesiologist |
| Noelle McCutchen | ... | Nurse Vivian |
| Linda Eve Miller | ... | E.R. Nurse |
| Dan Wilson | ... | Radiology Tech |
Season 2, Episode 5: Bring the Pain
23 October 2005A storm rages in Seattle. Izzie is very disappointed by her date with Alex, and Meredith is upset with Derek. They both complain to George, which drives him crazy. At the hospital, Cristina has a patient that uses porn as a pain killer and Meredith takes care of an Asian girl who needs to see a Shaman before surgery. There is a power shortage and George and Alex are stuck in an elevator with a critical patient. They need to perform heart surgery, but Alex is too freaked out and so George does it.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
 | Mimi Kennedy | ... | Verna Bradley |
 | François Chau | ... | Mr. Chue (as Francois Chau) |
 | Brent Briscoe | ... | Henry Lamott |
 | Michelle Krusiec | ... | Anna Chue |
 | Daniel Bess | ... | Pete Willoughby |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Sean Moran | ... | Lou Bradley |
 | Sally Ann Brooks | ... | Marie Lamont |
| Bashir Salahuddin | ... | Bailey's Husband |
| Jeremy Rabb | ... | ER Resident |
Season 2, Episode 6: Into You Like a Train
30 October 2005A train wreck brings multiple casualties to Seattle Grace, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his "mojo" a disheartening experience, and Yang searches high and low for a missing appendage.
Season 2, Episode 7: Something to Talk About
6 November 2005Addison and Derek go to marriage counseling. Derek says that he's finished with Meredith. Meanwhile, Meredith becomes the main gossip topic in the hospital and Izzie and Christina discover a pregnant man. Preston tells the Chief about him and Christina and Alex finally kisses Izzie.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Michelle Ongkingco | ... | Nicole Verma |
| Elaine Kagan | ... | Kimberly Griswold |
| Francis Guinan | ... | Mr. Verma |
| Reni Santoni | ... | Mr. Griswold |
 | Patti Yasutake | ... | Mrs. Verma |
 | Joseph Sikora | ... | Shane Herman |
 | Tyrees Allen | ... | Dr. Saltzman |
| Steven W. Bailey | ... | Joe |
| Moe Irvin | ... | Nurse Tyler Christian |
| Alison Ward | ... | Tina Herman |
 | Cathy Lind Hayes | ... | Nurse Debbie |
| Kerry Carney | ... | Intern #1 |
 | Maile Flanagan | ... | Lab Tech |
| Peyton Hinson | ... | Intern #2 |
 | Keeshan Giles | ... | Intern #3 |
 | Larry Weissman | ... | Psych Patient #1 |
| Gianin Loffler | ... | Psych Patient #2 |
| Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 2, Episode 8: Let It Be
13 November 2005Freinds of Derek and Addison come from New York, because the woman wants a preventative hysterectomy and mastectomy because she is afraid of cancer. Meanwhile, George is freaking out because he almost got hit by a man falling from a roof.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Arija Bareikis | ... | Savannah |
 | Joseph Lyle Taylor | ... | Weiss |
 | Shelley Berman | ... | Jed Sorento |
| Geoffrey Rivas | ... | Stu Vargas |
 | Brittany Ishibashi | ... | Talia |
 | Janet Rotblatt | ... | Esme Sorento |
 | Kate Blumberg | ... | Daisy |
 | Kai Lennox | ... | Speed |
| Kathleen M. Darcy | ... | Anesthesiologist |
 | Ray Ford | ... | Ray the Paramedic |
| Brian Reid | ... | Walter |
| Linda Klein | ... | Nurse Linda |
Season 2, Episode 9: Thanks for the Memories
20 November 2005Thanksgiving sends the occupants of the house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner that it appears no one is coming to.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Brian Kerwin | ... | Holden McKee |
 | Greg Pitts | ... | Jerry O'Malley |
 | Tim Griffin | ... | Ronny O'Malley |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Steven W. Bailey | ... | Joe |
 | Andrew James Allen | ... | Colby McKee |
| Michael Matthys | ... | Dr. Kent |
| Dee Nelson | ... | Cheryl Leonard |
 | Mike Faiola | ... | Guy |
| Peter Howard | ... | Hal Leonard |
 | Jack Yang | ... | Walter |
 | Gregor Manns | ... | Levi Johnson |
| George Dzundza | ... | Harold O'Malley (uncredited) |
Season 2, Episode 10: Much Too Much
27 November 2005Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Curtis Armstrong | ... | Robert Martin |
 | Margaret Welsh | ... | Dorie Russell |
 | Pat Healy | ... | Tom Russell |
 | Sunkrish Bala | ... | Steve Murphy |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Robin Pearson Rose | ... | Patricia |
| Pedro Barreira | ... | Kevin |
 | Jon Hershfield | ... | Doyle |
Season 2, Episode 11: Owner of a Lonely Heart
4 December 2005The mother of the quints blames herself, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina cares for an inmate desperate to stay at the hospital.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Rosanna Arquette | ... | Constance Ferguson |
 | Timothy Bottoms | ... | Carl Murphy |
| Margaret Welsh | ... | Dorie Russell |
| Pat Healy | ... | Tom Russell |
| Curtis Armstrong | ... | Robert Martin |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Patricia Bethune | ... | Nurse Ginger |
 | Monica Garcia | ... | Peds Nurse |
 | Elaine Kao | ... | NICU Nurse |
 | Brooke Blanchard | ... | Jill the Paramedic |
 | Amie Donegan | ... | NICU Nurse #2 |
Season 2, Episode 12: Grandma Got Run Over by a Reindeer
11 December 2005Christmas brings a range of holiday spirits, from über-cheer to Scrooge, and holiday maladies.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Jenny O'Hara | ... | Nadia's Mother |
 | Helen Slater | ... | Nadia Shelton |
| Michael Hyatt | ... | Marian Davidson |
 | Andrew Bilgore | ... | Tim Epstein |
| Kathe E. Mazur | ... | Mrs. Epstein (as Kathe Mazur) |
 | Richard Jenik | ... | Jimmy Shelton |
 | C.J. Sanders | ... | Justin Davidson (as CJ Sanders) |
| Steven W. Bailey | ... | Joe |
| Robin Pearson Rose | ... | Patricia |
 | Alan Fudge | ... | Ernie |
| Troy Curvey Jr. | ... | Father Michael |
| Kathleen M. Darcy | ... | Anesthesiologist |
| Alex Stamm | ... | Josh Shelton |
| Linda Klein | ... | Nurse Linda |
| Sarah McDermott | ... | Leah Epstein |
| Sean McDermott | ... | Jake Epstein |
| Savannah McDermott | ... | Jesse Epstein |
| John Cappon | ... | John the Paramedic |
| David Foy | ... | M.R.I. Tech (uncredited) |
Season 2, Episode 13: Begin the Begin
15 January 2006Izzie realizes that she is attracted to her patient with a heart condition. George treats Bex, a hermaphrodite. Meredith's mother gets a special visitors. Derek and Addison's relationship is still rocky.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Stephen Spinella | ... | Malar Pascowitz |
 | Jeffrey Dean Morgan | ... | Denny Duquette |
 | Lauren Tom | ... | Audrey |
| John Prosky | ... | Mr. Singleton |
| Becca Gardner | ... | Bex Singleton |
| Shannon Cochran | ... | Mrs. Singleton |
| Kate Burton | ... | Ellis Grey |
| Joyce Guy | ... | Ms. Henry |
 | Rob Narita | ... | Anesthesiologist |
| Linda Klein | ... | Nurse Linda |
| Anjul Nigam | ... | Dr. Raj Sen (uncredited) |
Season 2, Episode 14: Tell Me Sweet Little Lies
22 January 2006Meredith has to choose between her dog and her roommates, Alex gets his board results, and Bailey's pregnancy may be at risk.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Carole Cook | ... | Sophie Larson |
| Donovan Leitch | ... | Rick Friart |
| Nancy Linari | ... | Sophie's Daughter |
| Robin Pearson Rose | ... | Patricia |
| Cathy Lind Hayes | ... | Nurse Debbie |
 | Jill Holden | ... | Naomi Cline |
| Christopher Boyer | ... | Tom Cline |
| John O'Brien | ... | Jeffrey |
 | Ricardo Molina | ... | ID Resident Amir |
 | Rigo Sanchez | ... | Stan the Paramedic |
 | Natalie N. Okamoto | ... | Yumi Miyazaki |
 | Kate Anthony | ... | Nurse Kate |
| Yutaka Takeuchi | ... | Kamaji |
| Tyshawn Bryant | ... | Friend #1 |
 | Justin Sandler | ... | Guitar Player (uncredited) |
Season 2, Episode 15: Break on Through
29 January 2006The nurses strike, leaving the doctors unprepared for their extra duties. Cristina and Burke have to define their work relationship, Izzie relates to a pregnant teenager, and Meredith finds parallels to her mother in a case requiring her to remove life support.
Season 2, Episode 16: It's the End of the World
5 February 2006The lives of everyone in the OR are threatened when a patient enters with a bomb inside of him... and a young paramedic with her arm inside the cavity is the only thing keeping it from going off.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Christina Ricci | ... | Hannah Davies |
| Kyle Chandler | ... | Dylan Young |
 | Jillian Armenante | ... | Mindy Carlson |
| Cress Williams | ... | Tucker Jones |
 | Larry Clarke | ... | Paul |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Cathy Lind Hayes | ... | Nurse Debbie |
| Moe Irvin | ... | Nurse Tyler Christian |
| Kathleen M. Darcy | ... | Anesthesiologist |
| Marty Lodge | ... | Dr. Milton |
 | John Bishop | ... | James Carlson |
| O. Austin Rey | ... | Bomb Squad #1 |
 | Jamal Thomas | ... | Larry the Paramedic |
Season 2, Episode 17: As We Know It
12 February 2006While the man with the bomb lodged in his chest remains in Burke's OR, Bailey's injured husband remains in Derek's. Meanwhile, Bailey still hasn't delivered her baby.
Season 2, Episode 18: Yesterday
19 February 2006Derek and Addison are shaken by the arrival of someone from their past. Meanwhile, Burke learns Cristina's secret, and Meredith delves into her family's dirty laundry.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Eric Dane | ... | Dr. Mark Sloan |
| Jeff Perry | ... | Thatcher Grey |
| Julio Oscar Mechoso | ... | Chuck Eaton |
 | Arlene Tur | ... | Pamela Calva |
 | Jesse Plemons | ... | Jake Burton |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Carlos Cervantes | ... | Mr. Calva (as Carlos Cervantes) |
 | Deborah Geffner | ... | Mrs. Burton |
 | David Grant Wright | ... | Mr. Burton |
| Brooke Blanchard | ... | Jill the Paramedic |
 | Ariel Felix | ... | CT Tech |
| Chad Fish | ... | Anesthesiologist |
 | Gary Houck | ... | MRI Technician (uncredited) |
Season 2, Episode 19: What Have I Done to Deserve This?
26 February 2006Karma figures large in the minds of most of the staff for various reasons, and Meredith and George face the repercussions of their actions.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Sara Ramirez | ... | Dr. Callie Torres |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Ann Cusack | ... | Amy |
 | Jonathan Slavin | ... | Rick |
 | Mark Harelik | ... | Keith Polace |
 | Matt Roth | ... | Michael |
| Cress Williams | ... | Tucker Jones |
| Sarah Utterback | ... | Nurse Olivia Harper |
 | Noah Gray-Cabey | ... | Shawn Beglight |
| Cathy Lind Hayes | ... | Nurse Debbie |
| Jeremy Rabb | ... | ER Resident |
| Ray Ford | ... | Ray the Paramedic |
Season 2, Episode 20: Band-Aid Covers the Bullet Hole
12 March 2006Cristina babysits for Bailey and doesn't take to it well at all. Meanwhile, Addison and Derek come to terms with their relationship, and Denny keeps coming between Alex and Izzie.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
 | Teddy Dunn | ... | Heath Mercer |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Stephen Lee | ... | Mr. Gibson |
| Tim Rhoze | ... | Kyle Booker (as Tim Edward Rhoze) |
 | Natalie Cole | ... | Sylvia Booker |
 | Kelley Hazen | ... | Mrs. Mercer |
 | Anne Moore | ... | Penny Gibson |
| Ray Ford | ... | Ray the Paramedic |
| Helene McCardle | ... | ER Doc |
Season 2, Episode 21: Superstition
19 March 2006A complication from the LVAD surgery puts Denny in the OR during a death cycle, Cristina maneuvers to get George kicked out, and an old mentor of the Chief's is admitted for treatment.
Season 2, Episode 22: Under Pressure
23 April 2006Clip show that summarizes season 2 thus far.
| Ellen Pompeo | ... | Dr. Meredith Grey (archive footage) |
| Sandra Oh | ... | Dr. Cristina Yang (archive footage) |
| Katherine Heigl | ... | Dr. Izzie Stevens (archive footage) |
| Justin Chambers | ... | Dr. Alex Karev (archive footage) |
| T.R. Knight | ... | Dr. George O'Malley (archive footage) |
| Chandra Wilson | ... | Dr. Miranda Bailey (archive footage) |
| James Pickens Jr. | ... | Dr. Richard Webber (archive footage) |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd (archive footage) |
| Isaiah Washington | ... | Dr. Preston Burke (archive footage) |
| Patrick Dempsey | ... | Dr. Derek Shepherd (archive footage) |
| Steven W. Bailey | ... | Joe / Narrator (also archive footage) |
Season 2, Episode 23: Blues for Sister Someone
30 April 2006While Izzie grills George about the personal details of his life, Addison takes Alex to task about a sensitive case. Also, Burke feels the pressure when he treats his musical hero, and Meredith considers dating a hunky vet.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Chris O'Donnell | ... | Dr. Finn Dandridge |
| Sara Ramirez | ... | Dr. Callie Torres |
 | Jayne Brook | ... | Gwen Graber |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Albert Hall | ... | Eugene Foote |
 | Jean Louisa Kelly | ... | Rose Ward |
 | Andrew Borba | ... | Chris Ward |
| Kathleen M. Darcy | ... | Burke's Anesthesiologist |
| Noelle McCutchen | ... | Nurse Vivian |
 | Bryce Robinson | ... | Timothy Ward |
Season 2, Episode 24: Damage Case
7 May 2006The interns care for a family involved in a car accident. Derek lets his emotions get the better of him.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
| Sara Ramirez | ... | Dr. Callie Torres |
 | John Cho | ... | Marshall Stone |
| Jeffrey Dean Morgan | ... | Denny Duquette |
| Graham Beckel | ... | Jim Johnson (as Graham S. Beckel) |
 | Sarah Lafleur | ... | Melanie Reynolds (as Sarah LaFleur) |
 | Gabriel Tigerman | ... | Noah Reynolds |
 | Frances Fisher | ... | Betty Johnson |
| John O'Brien | ... | CT Tech #2 |
 | Wayne Lopez | ... | Paramedic #2 |
| Maile Flanagan | ... | CT Tech #1 |
| Ray Ford | ... | Ray the Paramedic |
 | P.D. Mani | ... | Anesthesiologist |
| Maria Elena Maglaris | ... | Nurse Maria |
Season 2, Episode 25: 17 Seconds
14 May 2006Burke and Izzie continue to search for a new heart. The residents treat victims of a workplace shooting.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
| Sara Ramirez | ... | Dr. Callie Torres |
| Jeffrey Dean Morgan | ... | Denny Duquette |
 | Brooke Smith | ... | Dr. Erica Hahn |
 | Ken Marino | ... | Brad Ackles |
 | Michael Milhoan | ... | Doug Thomas |
 | Sydney Tamiia Poitier | ... | Deborah Fleiss |
| Jesse Head | ... | Will |
 | Michael Arden | ... | Neal Hannigan |
| Steven W. Bailey | ... | Joe |
| Robin Pearson Rose | ... | Patricia |
| Patti Tippo | ... | Cindy Thomas |
| Kathleen M. Darcy | ... | Derek's Anesthesiologist |
| Jeremy Rabb | ... | ER Resident |
 | Keith Sellon-Wright | ... | Surgeon #1 |
 | Carmen Mormino | ... | Monnie |
 | David Paluck | ... | Surgeon #2 |
 | Kate Mines | ... | Burke's Nurse |
 | Toby Meuli | ... | Chaz |
 | Jennifer Nyholm | ... | Kendra Thomas (uncredited) |
Season 2, Episode 26: Deterioration of the Fight or Flight Response
15 May 2006The struggle to get Denny a heart continues. Christina gets to run her own trauma. Shepherd is responsible for a friend's life. The Chief's niece is brought to the ER by his wife.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Jeffrey Dean Morgan | ... | Denny Duquette |
| Loretta Devine | ... | Adele Webber |
| Brooke Smith | ... | Dr. Erica Hahn |
 | Tessa Thompson | ... | Camille Travis |
 | Hallee Hirsh | ... | Claire |
 | Tiffany Hines | ... | Natalie |
| Sarah Utterback | ... | Nurse Olivia Harper |
 | Charles Duckworth | ... | Brian |
| Keith Sellon-Wright | ... | Surgeon #1 |
| Jeremy Rabb | ... | ER Resident |
| Ariel Felix | ... | Anesthesiologist |
| David Paluck | ... | Surgeon #2 |
| Linda Klein | ... | Nurse Linda |
Season 2, Episode 27: Losing My Religion
15 May 2006The chief tries to determine who's responsible. Callie presses George about his feelings. Derek and Meredith have to make a decision about Doc. The interns are charged with pleasing the chief's niece.
Season 3
Season 3, Episode 1: Time Has Come Today
21 September 2006When Izzie has a mental collapse after Denny's death, Izzie and Cristina turn to Meredith to try and make it better for her. Callie tries to cope with George not returning the three word sentiment she said to him. Meanwhile, back at the hospital, Alex and Addison deal with a baby left in a garbage can at a local high school, Richard receives an ultimatum from his wife, and Derek and George are quarantined in the locker room due to a patient suspected of having the plague.
Season 3, Episode 2: I Am a Tree
21 September 2006Patients include a teenage boy with a tree run through him, a man with a tumor on his brain that forces him to be honest, and a patient who goes all out on living before her surgery as the interns begin to go all out on Bailey to ask Izzie to come back to Seattle Grace; Dr. Burke's mother goes all out on breaking Cristina's will; Addison goes all out with the bottle because she found some interesting pocket fanfare in her husband's tuxedo after the prom; and Callie goes all out to make George jealous.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
 | Richard Roundtree | ... | Donald Burke |
 | Roxanne Hart | ... | Dana Seabury |
 | Peter Paige | ... | Benjamin O'Leary |
| Steven W. Bailey | ... | Joe |
 | Elizabeth Sampson | ... | Ruth O'Leary |
| Javier Grajeda | ... | Jeffrey Hernandez |
 | Diahann Carroll | ... | Jane Burke |
| Moe Irvin | ... | Nurse Tyler Christian |
| Brandon Melgar | ... | Harley |
 | Zibby Allen | ... | Cute Nurse |
| Brooke Blanchard | ... | Jill the Paramedic |
| Eric Dane | ... | Dr. Mark Sloan (uncredited) |
| Harris Michaels | ... | Orderly (uncredited) |
Season 3, Episode 3: Sometimes a Fantasy
5 October 2006Cristina refuses to quit, like she thinks Preston has. Finn and Derek refuse to quit on Meredith, who insist that they date her. Izzie won't quit standing out front of Seattle Grace, waiting for the time she feels is right to see Dr. Webber. Mark won't quit on giving up on Addison, who now realizes her marriage to Derek is over. And Alex wishes she would quit picking him as her intern in the OB-GYN department.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
 | Abigail Breslin | ... | Megan Clover |
| Jack Conley | ... | Jasper Hovey |
| Gabriel Casseus | ... | Taylor Tressel |
| Lanei Chapman | ... | Lianne Tressel (as Lanai Chapman) |
 | Stephanie Erb | ... | Mrs. Gantry |
 | Kevin Will | ... | Len Gantry |
| Linda Eve Miller | ... | E.R. Nurse |
 | Daniel Tatar | ... | Clerk #1 |
| Julie Granata | ... | Clerk #2 |
 | Mo Hines | ... | Hospital patient (uncredited) |
Season 3, Episode 4: What I Am
12 October 2006Denny's father (Fred Ward) visits Izzie and gives her something that will change everything. Meanwhile, Meredith is diagnosed with appendicitis and while waiting for emergency surgery and high on morphine has a talk with Addison for the first time since Addison found the panties. Mark "McSteamy" Sloan starts working at the hospital and Alex wants to work under him instead of Addison because Mark has a patient with severe facial burns. And while Callie and George break up, Meredith finally picks one man.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery-Shepherd |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Chris O'Donnell | ... | Dr. Finn Dandridge |
 | Fred Ward | ... | Denny Duquette, Sr. |
| Stephanie Faracy | ... | Mrs. Sullivan |
| Tina Holmes | ... | Rebecca Bloom |
 | Alan Blumenfeld | ... | Shawn Sullivan |
| Steven W. Bailey | ... | Joe |
| Jeff Rubino | ... | Jeff Bloom |
| Paula Weston Solano | ... | OB Nurse |
| Jeffrey Dean Morgan | ... | Denny Duquette (voice) (uncredited) |
Season 3, Episode 5: Oh, the Guilt
19 October 2006Guilt causes different actions in everyone, the interns are allowed to attend an M&M meeting, and Derek and Addison finalize things.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Faith Prince | ... | Sonya Cowlman |
 | Arye Gross | ... | Adam Morris |
 | Justina Machado | ... | Anna Nyles |
| Chris Conner | ... | Mr. Nyles |
 | Margo Harshman | ... | Jennifer Morris |
 | Todd Babcock | ... | Dr. Matthew Savoy |
| Moe Irvin | ... | Nurse Tyler Christian |
| Kate Anthony | ... | Nurse Kate |
 | Karl T. Wright | ... | Mediator |
| Libby Barnes | ... | Dr. #1 |
| Tom Ormeny | ... | Dr. #2 |
Season 3, Episode 6: Let the Angels Commit
2 November 2006Derek's sister comes to Seattle for a visit, and seems more into the extended family and gossip surrounding his divorce from Addison than into him. Meanwhile, the interns are not the only ones jealous of Cristina's opportunity to scrub in with Preston on a "Humpty Dumpty" procedure, and Bailey takes it personally when she learns she's been scrubbed, herself. George works with Addison on a very unusual case and Alex envies him.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Jillian Bach | ... | Gretchen |
| Edwin Hodge | ... | Greg Stanton |
| Liza Lapira | ... | Noelle Lavatte |
| Francesca P. Roberts | ... | Mrs. Bird |
| Patricia Bethune | ... | Nurse Ginger |
| Moe Irvin | ... | Nurse Tyler Christian |
| Jeremy Rabb | ... | ER Resident |
| Yvette Cruise | ... | Scrub Nurse |
| Martin Yu | ... | Resident #2 |
| Paula Weston Solano | ... | OB Nurse |
 | Jack Axelrod | ... | Really Old Guy |
 | Embeth Davidtz | ... | Nancy Shepherd (uncredited) |
Season 3, Episode 7: Where the Boys Are
9 November 2006Derek was looking forward to getting away from it all for a few days until his co-workers all go along on a camping trip. Bailey confronts Cristina and another doctor confronts Izzie about her feelings surrounding Denny. Addison and Callie are confronted by a major problem with a pregnant patient.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| George Dzundza | ... | Harold O'Malley |
 | Kali Rocha | ... | Dr. Sydney Heron |
 | Clare Carey | ... | Nikki Gibson |
 | Alexandra Billings | ... | Donna Gibson |
| Alexandra Holden | ... | Jamie Carr |
 | Jim Parrack | ... | Ted Carr |
| Steven W. Bailey | ... | Joe |
| Jack Yang | ... | Walter |
| Moe Irvin | ... | Nurse Tyler Christian |
 | Joshua Cabrera | ... | Eric Sanborn |
 | Monica Sanchez | ... | Holly Sanborn |
Season 3, Episode 8: Staring at the Sun
16 November 2006George must deal with his family when his father is admitted, Richard comes to a decision about his marriage, and Burke's secret is closer to getting out.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| George Dzundza | ... | Harold O'Malley |
 | Myndy Crist | ... | Mrs. Hanson |
| Greg Pitts | ... | Jerry O'Malley |
| Tim Griffin | ... | Ronny O'Malley |
 | Matt Winston | ... | Frank Jeffries |
 | Paul Cassell | ... | Mr. Hanson |
 | Annie Campbell | ... | Anna |
| Steven W. Bailey | ... | Joe |
| Kate Burton | ... | Ellis Grey |
| Ray Ford | ... | Ray the Paramedic |
| Martin Yu | ... | Resident |
 | Brad Sachs | ... | Tech |
Season 3, Episode 9: From a Whisper to a Scream
23 November 2006A traumatic car accident fills the ER; Cristina has a crisis of conscience about her deceptive teamwork with Burke; Izzie pushes the boundaries of probation.
Season 3, Episode 10: Don't Stand So Close to Me
30 November 2006Miranda is adamant that Burke and Cristina be punished, Derek doubts his abilities, Izzie takes a stand, and Meredith deals with family in two very different ways.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| George Dzundza | ... | Harold O'Malley |
| Brooke Smith | ... | Dr. Erica Hahn |
| Debra Monk | ... | Louise O'Malley |
 | Jennifer Aspen | ... | Elena |
| Greg Pitts | ... | Jerry O'Malley |
| Tim Griffin | ... | Ronny O'Malley |
 | Mandy Siegfried | ... | Molly Thompson |
 | Jason Sklar | ... | Jake Weitzman |
| Randy Sklar | ... | Peter Weitzman |
 | Mare Winningham | ... | Susan Grey |
| Kate Burton | ... | Ellis Grey |
| Jack Axelrod | ... | Really Old Guy |
| Linda Klein | ... | Nurse Linda |
Season 3, Episode 11: Six Days: Part 1
11 January 2007As Mr. O'Malley's surgery approaches, he begins to suspect how serious his condition is, Izzie has to take a positive step to scrub in on a surgery, and Meredith keeps running in to her father.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| George Dzundza | ... | Harold O'Malley |
| Jeff Perry | ... | Thatcher Grey |
| Debra Monk | ... | Louise O'Malley |
| Greg Pitts | ... | Jerry O'Malley |
| Tim Griffin | ... | Ronny O'Malley |
 | Mae Whitman | ... | Heather Douglas |
 | Judith Hoag | ... | Rhada Douglas |
| Sarah Utterback | ... | Nurse Olivia Harper |
| John O'Brien | ... | Lab Guy |
| Elaine Kao | ... | NICU Nurse |
| Rhomeyn Johnson | ... | Manager |
| Jake Mailey | ... | Uncle Jim |
 | Michael James Thompson | ... | Cousin Joe |
Season 3, Episode 12: Six Days: Part 2
18 January 2007George's dad has a rocky road to recovery, Cristina and Burke continue their war of silence, and Meredith reaches out to her father.
Season 3, Episode 13: Great Expectations
25 January 2007George deals with his grief, Cristina and Burke's not talking makes for an interesting dinner party, and the Chief has made an decision that sends all the attending doctors scrambling.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Loretta Devine | ... | Adele Webber |
 | Rachel Boston | ... | Rachel |
 | Jessica Stroup | ... | Jillian Miller |
 | Joe Holt | ... | Steve Beck |
| Michael P. Byrne | ... | Mr. Miller |
 | Kathleen Mary Carthy | ... | Mrs. Miller |
Season 3, Episode 14: Wishin' and Hopin'
1 February 2007A toxic cancer patient immobilizes the hospital, George has an announcement, and Izzie frets that her money wasn't well spent. Meredith, meanwhile, has new issues with her mother and Cristina worries that having a personal life could affect her career.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Kate Burton | ... | Ellis Grey |
 | Matt McTighe | ... | Vincent |
 | Ronobir Lahiri | ... | Mr. Hanson |
| Jasmine Di Angelo | ... | Kelley Hanson |
| Joyce Guy | ... | Ms. Henry |
| Kate Anthony | ... | Nurse Kate |
| Maile Flanagan | ... | Lab Tech |
 | Amanda Collins | ... | Marina |
| Tony Adelman | ... | Hurts When He Pees |
 | David J. Lee | ... | Sprained Ankle |
 | Liz Montgomery | ... | Coughing Lady |
Season 3, Episode 15: Walk on Water
8 February 2007The interns face a mass-casualty incident while George crosses the professional line with Callie, Cristina asks Preston to let her tell Meredith about their engagement before anyone else finds out, and the Chief dons a new hair style.
Season 3, Episode 16: Drowning on Dry Land
15 February 2007Cristina keeps an eye out around the hospital for Meredith to tell her about her impending nuptials. Izzie fights for the life of her patient, still trapped between two vehicles on the ferry and Derek also searches for Meredith, wondering where she's disappeared to. Alex gets the job of notifying friends and family members about the status of loved ones.
Season 3, Episode 17: Some Kind of Miracle
22 February 2007Meredith interacts with some memories, all while the Chief, Burke and Bailey devise an unusual resuscitation maneuver. Meanwhile, Cristina has her own therapy and Derek speaks his mind to Ellis.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Jeffrey Dean Morgan | ... | Denny Duquette |
| Kyle Chandler | ... | Dylan Young |
 | Elizabeth Reaser | ... | Jane Doe |
| Anna Maria Horsford | ... | Liz Fallon |
 | Monica Keena | ... | Bonnie Crasnoff |
| Kali Rocha | ... | Dr. Sydney Heron |
| Steven W. Bailey | ... | Joe |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Kate Burton | ... | Ellis Grey |
| Moe Irvin | ... | Nurse Tyler Christian |
| David Downs | ... | Man |
| Yvette Cruise | ... | ICU Nurse |
| Billy Wood | ... | Perfectionist |
Season 3, Episode 18: Scars and Souvenirs
15 March 2007A Korean war veteran with an old bullet left in his shoulder is admitted into Seattle Grace. Tensions escalate between Izzie and George, and Callie must reveal a big secret. Alex continues to work with Jane Doe.
Season 3, Episode 19: My Favorite Mistake
22 March 2007Izzie seems to be the only one with a memory of the previous night, Derek gets over-protective when Meredith gets a surgery, and one of Callie's relatives comes to town.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Elizabeth Reaser | ... | Jane Doe |
 | Michael Boatman | ... | Doug Kendry |
 | Roger Rees | ... | Dr. Colin Marlow |
 | Catherine Dent | ... | Cathy Rogerson |
 | Elisabeth Moss | ... | Nina Rogerson |
 | Hector Elizondo | ... | Carlos Torres |
| Judi Barton | ... | Board Member |
Season 3, Episode 20: Time After Time
19 April 2007Meredith deals with an overbearing step-mother. Christina finds herself caught between Burke and Marlow. Derek fights for the job of Chief. Alex continues the search for Jane Doe's identity. And Izzie's past comes looking for her.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Elizabeth Reaser | ... | Jane Doe / Ava |
| Roger Rees | ... | Dr. Colin Marlow |
 | Dee Wallace | ... | Joan Waring |
| Brent Jennings | ... | Charles Redford |
 | Suzanne Cryer | ... | Caroline Klein |
 | Tim Hopper | ... | Dustin Klein |
 | Marc Vann | ... | Hematologist |
| Steven W. Bailey | ... | Joe |
| Mare Winningham | ... | Susan Grey |
 | Randy Thompson | ... | Frank Waring |
 | Melissa Fitzgerald | ... | Social Worker |
| Kate Anthony | ... | Nurse Kate |
| Zibby Allen | ... | Nurse Zibby |
 | Nichelle Hines | ... | Young Woman |
 | Liv Hutchings | ... | Hannah |
| Craig Tsuyumine | ... | TV Reporter |
Season 3, Episode 21: Desire
26 April 2007The Chairman of Seattle Grace's board of directors is admitted and all the attendings vie for his favor, Izzy and George keep getting confronted by the results of infidelity, and Preston presses Cristina for a decision.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Elizabeth Reaser | ... | Jane Doe / Ava |
| Kali Rocha | ... | Dr. Sydney Heron |
 | Mitch Pileggi | ... | Larry Jennings |
 | Mary-Margaret Humes | ... | Nancy Jennings |
 | Rowena King | ... | Celeste Newman |
 | Ramon De Ocampo | ... | James Benton |
 | Stewart Skelton | ... | Dr. Fischer |
 | Joseph Sun | ... | Intern (uncredited) |
Season 3, Episode 22: The Other Side of This Life: Part 1
3 May 2007Addison leaves for warmer climes and to figure things out, Susan visits the clinic, and Cristina's perfect wedding is changed when her and Burke's mothers hit town.
Season 3, Episode 23: The Other Side of This Life: Part 2
3 May 2007Addison is pulled into the case of a high-risk surrogate mother, Susan develops a complication, Izzy struggles with George's decision, and Ava has surgery that may restore her memory.
Season 3, Episode 24: Testing 1-2-3
10 May 2007The interns take the biggest test of their careers, their first-year medical exams, as the residents attend to three injured mountain climbers. Meanwhile Callie's suspicions of George and Izzie grow, and Cristina struggles to write her wedding vows.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Elizabeth Reaser | ... | Jane Doe / Rebecca Pope / Ava |
| Jeff Perry | ... | Thatcher Grey |
| Steven W. Bailey | ... | Joe |
| Aasha Davis | ... | Rina |
 | Kevin Rankin | ... | Jack Vaughan |
 | Brian Tee | ... | Andy |
| Jack Yang | ... | Walter |
 | Derek Phillips | ... | Dale |
| Mandy Siegfried | ... | Molly Thompson |
| Loretta Devine | ... | Adele Webber |
 | Tim Chiou | ... | Paramedic |
| Nicole Cummins | ... | Paramedic Nicole (as Nicole Cummins-Rubio) |
| Michelle N. Carter | ... | Proctor |
 | Chyler Leigh | ... | Dr. Lexie Grey (uncredited) |
Season 3, Episode 25: Didn't We Almost Have It All?
17 May 2007The wedding day arrives, and Cristina desperately needs something to take her mind off it, the fourth climber is found and his condition doesn't match the other climbers' stories, and Adele's condition brings a change for Richard.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Kate Walsh | ... | Dr. Addison Montgomery |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Isaiah Washington | ... | Dr. Preston Burke |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Elizabeth Reaser | ... | Jane Doe / Rebecca Pope / Ava |
 | Jason London | ... | Jeff Pope |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Steven W. Bailey | ... | Joe |
| Tsai Chin | ... | Helen Rubenstein |
| Aasha Davis | ... | Rina |
| Kevin Rankin | ... | Jack Vaughan |
| Brian Tee | ... | Andy |
| Jack Yang | ... | Walter |
| Derek Phillips | ... | Dale |
| Robin Pearson Rose | ... | Patricia |
| Loretta Devine | ... | Adele Webber |
| Diahann Carroll | ... | Jane Burke |
 | Ajay Vidure | ... | Intern 1 |
 | Candice Afia | ... | Intern Laura |
 | Artie O'Daly | ... | Intern 3 |
 | Joseph Williamson | ... | Intern Pierce |
 | Traber Burns | ... | Andy's Lawyer |
 | Marie Antoinette | ... | Family Friend (uncredited) |
Season 4
Season 4, Episode 1: A Change Is Gonna Come
27 September 2007The interns, now residents, deal with their own crops of interns. Callie struggles with her new position, and Burke makes a decision.
Season 4, Episode 2: Love/Addiction
4 October 2007Lexie persists in trying to get to know Meredith, and Mama Burke descends once more.
Season 4, Episode 3: Let the Truth Sting
11 October 2007Callie hides in her office, frustrating Bailey who's itching to teach someone, and age becomes the theme as Izzie tries to convince 'Really Old Guy' he shouldn't die, Webber and Sloan set out to prove they're not too old to learn a new technique, and Karev is saddled with an intern who's past his prime.
Season 4, Episode 4: The Heart of the Matter
18 October 2007Meredith and her intern lose a patient after they give her the wrong diagnosis, Callie confronts Izzie, and McDreamy bonds with the other Grey.
Season 4, Episode 5: Haunt You Every Day
25 October 2007Meredith feels she's being haunted by her Mother's ashes, and Cristina is denied a surgery for a surprising reason.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Edward Herrmann | ... | Dr. Norman Shales |
| Elizabeth Reaser | ... | Ava |
| Rocky Carroll | ... | James |
| Kali Rocha | ... | Dr. Sydney Heron |
 | David Clennon | ... | Jack Shandley |
 | Dylan Minnette | ... | Ryan |
| Sarah Utterback | ... | Nurse Olivia Harper |
| Anjul Nigam | ... | Dr. Raj Sen |
 | Bhama Roget | ... | Erin Shandley |
 | Crystal Kwon | ... | Nurse Jolene |
 | Jeremiah Hu | ... | Fingerless Guy |
| Ray Ford | ... | Ray the Paramedic |
| Linda Eve Miller | ... | E.R. Nurse |
| Suzanne Quinn | ... | Clinic Nurse |
 | Arlene Santana | ... | Nurse (uncredited) |
Season 4, Episode 6: Kung Fu Fighting
1 November 2007A man survives a parachute accident without serious injury, two women refuse treatment because of a wedding contest, and Cristina and Izzie jockey for inclusion in Hahn's surgeries.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | David Denman | ... | Rick Jacobs |
 | Cullen Douglas | ... | Mr. Arnold |
 | Marina Black | ... | Sally |
 | Tommy Dewey | ... | Mike |
 | Amanda Loncar | ... | Jackie Escott |
 | Steve Sandvoss | ... | Jason |
 | Chryssie Whitehead | ... | Helena Boye |
 | John Balma | ... | Contest Judge |
| John Cappon | ... | John the Paramedic |
| Nicole Cummins | ... | Nicole the Paramedic (as Nicole Rubio) |
Season 4, Episode 7: Physical Attraction... Chemical Reaction
8 November 2007Hahn bans Cristina from her service, Bailey covers more and more of Torres' duties, and Izzie and George take go to extreme lengths to recapture the magic of their first encounter.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Jeff Perry | ... | Thatcher Grey |
 | Rockmond Dunbar | ... | Sean Brotherton |
| Stephanie March | ... | Jane |
 | Vicki Lewis | ... | Harriet |
 | David Burke | ... | Don |
| Kurt Fuller | ... | Jerry |
 | Enuka Okuma | ... | Teresa Brotherton |
 | Braeden Lemasters | ... | Brian |
 | Mark Saul | ... | Dr. Steve Mostow |
 | Amrapali Ambegaokar | ... | Intern Dani |
| Linda Eve Miller | ... | E.R. Nurse |
 | Tommy Gerrits | ... | Boy Who Lost Parents in a Car Accident (uncredited) |
 | Jamie McCall | ... | Nurse (uncredited) |
Season 4, Episode 8: Forever Young
15 November 2007Bailey crosses the line when the guy she had a crush on in high school shows up in the ER during an onslaught of high school students involved in a bus crash. The Grey sisters run and hide when their father shows up drunk, while Derek tries to get back into the dating scene with another doctor and Cristina tries her best to get back into Hahn's good graces.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Jeff Perry | ... | Thatcher Grey |
| Kali Rocha | ... | Dr. Sydney Heron |
| D.B. Woodside | ... | Marcus Kane (as DB Woodside) |
 | Lauren Stamile | ... | Nurse Rose |
 | Madeline Zima | ... | Marissa |
 | Brooke Nevin | ... | Tricia Hale |
 | Stephen Sowan | ... | Danny Metcalf |
| Ray Ford | ... | Ray the Paramedic |
 | Courtney Hope | ... | Ariana |
 | Julia Ling | ... | Emma |
 | Meghan Lynch | ... | Courtney |
| Mark Saul | ... | Dr. Steve Mostow |
 | Molly Kidder | ... | Dr. Megan Nowland |
 | Laura Kenley | ... | Jamie |
| Joseph Williamson | ... | Intern Pierce |
| Amrapali Ambegaokar | ... | Intern Dani |
| Rob J. Greenlea | ... | Second Paramedic |
 | Monica Herman | ... | Molly |
 | Ken Edling | ... | Doctor (uncredited) |
Season 4, Episode 9: Crash Into Me: Part 1
22 November 2007An accident in the ER bay leaves two paramedics fighting for their lives, and a third who refuses Bailey's care. Meanwhile Alex juggles two women, and Lexie begins to bond with a patient.
Season 4, Episode 10: Crash Into Me: Part 2
6 December 2007Tragedy abounds for everyone at Seattle Grace as they all continue in efforts to get the paramedic out of the overturned ambulance, stop the bleeding of a man who won't quit, and a bigot with a Nazi tattoo on his stomach. On the personal side, Rebecca returns to spend time with Alex, Miranda's husband finds it harder to wait for her while she's in surgery, and Cristina still tries to get on Hahn's good side, even though Bailey has put her elsewhere.
Season 4, Episode 11: Lay Your Hands on Me
10 January 2008Bailey's son comes to the ER, Derek takes a housing step that puts pressure on Meredith, Izzie has a crisis of faith, and Cristina's choice may change her course with Hahn.
Season 4, Episode 12: Where the Wild Things Are
24 April 2008The judgment of the residents is skewed by a competition, Meredith tries therapy and a bear attack may be more than it appears.
Season 4, Episode 13: Piece of My Heart
1 May 2008Addison is not prepared for all the changes that greet her upon her return to Seattle Grace for a specialized surgery, Meredith and Derek begin their clinical trial, Izzie feels left out, and Karev is confronted with an unexpected announcement.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Kate Walsh | ... | Dr. Addison Montgomery |
 | Amy Madigan | ... | Dr. Wyatt |
| Elizabeth Reaser | ... | Rebecca Pope |
 | Clea DuVall | ... | Jennifer Robinson (as Clea Duvall) |
| Lauren Stamile | ... | Nurse Rose |
 | Kathleen Rose Perkins | ... | Sarah |
 | Ken Barnett | ... | Freddie |
 | Jason O'Mara | ... | Phillip Robinson |
 | Sam Daly | ... | Will |
 | Meg Cionni | ... | Nikki |
| John O'Brien | ... | Lab Tech |
 | Gloria Garayua | ... | Intern Graziella |
 | Tymberlee Hill | ... | Intern Claire (as Tymberlee Chanel) |
| Winston Story | ... | Intern Leo |
| Joy Osmanski | ... | Intern Lucy |
| Molly Kidder | ... | Dr. Megan Nowland |
 | Richard Keith | ... | Intern Mitch |
Season 4, Episode 14: The Becoming
8 May 2008The new clinical trial patient has a secret, Yang is dealt a blow from a distance by Burke, the nurses refuse to work with Sloan, and Meredith's therapist tells her some home truths.
Season 4, Episode 15: Losing My Mind
15 May 2008Cristina is still in her slump and turning mean, Izzie finally confronts Ava/Rebecca, and Meredith's anger with her therapist is challenged by a patient with a Cinderella story.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Amy Madigan | ... | Dr. Wyatt |
| Elizabeth Reaser | ... | Rebecca Pope |
| Paul Dooley | ... | Dr. Walter Tapley |
| Regina Taylor | ... | Greta |
| Lauren Stamile | ... | Nurse Rose |
 | April Grace | ... | Greta's Sister |
| Cress Williams | ... | Tucker Jones |
 | Jeffrey D. Sams | ... | Andre |
| Jodi Riggins | ... | Intern (uncredited) |
Season 4, Episode 16: Freedom
22 May 2008A surgical team battles the clock as they try to save a boy encased in cement, Karev's situation with an ever-disintegrating Ava brings back painful memories that interfere with his judgment, Derek and Meredith have one last chance at their clinical trial.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
| Amy Madigan | ... | Dr. Wyatt |
| Elizabeth Reaser | ... | Rebecca Pope |
| Lauren Stamile | ... | Nurse Rose |
 | John Cothran Jr. | ... | Ken Monroe (as John Cothran) |
 | James Immekus | ... | Andrew Langston |
 | Kathryn Meisle | ... | Liz Monroe |
 | Marshall Allman | ... | Jeremy West |
 | Jana Kramer | ... | Lola |
| Loretta Devine | ... | Adele Webber |
 | Jurnee Smollett | ... | Beth Monroe |
 | Christian Alexander | ... | Will |
 | Stephen Bishop | ... | Firefighter |
| Molly Kidder | ... | Dr. Megan Nowland |
 | Sterling Knight | ... | Kip |
| Joy Osmanski | ... | Intern Lucy |
 | Jerry Zatarain | ... | David (as Jerry Zatarain Jr.) |
Season 5
Season 5, Episode 1: Dream a Little Dream of Me
25 September 2008Meredith and Derek find that "happily ever after" isn't as easy as they hoped, Cristina finds interest in a military doctor, and the Chief is surprised to hear that Seattle Grace is no longer ranked as a top-tier teaching hospital.
| Ellen Pompeo | ... | Dr. Meredith Grey |
| Sandra Oh | ... | Dr. Cristina Yang |
| Katherine Heigl | ... | Dr. Izzie Stevens |
| Justin Chambers | ... | Dr. Alex Karev |
| T.R. Knight | ... | Dr. George O'Malley |
| Chandra Wilson | ... | Dr. Miranda Bailey |
| James Pickens Jr. | ... | Dr. Richard Webber |
| Sara Ramirez | ... | Dr. Callie Torres |
| Eric Dane | ... | Dr. Mark Sloan |
| Chyler Leigh | ... | Dr. Lexie Grey |
| Brooke Smith | ... | Dr. Erica Hahn |
| Patrick Dempsey | ... | Dr. Derek Shepherd |
 | Kevin McKidd | ... | Dr. Owen Hunt |
 | Mariette Hartley | ... | Betty Kenner |
| Lauren Stamile | ... | Nurse Rose |
 | Cliff De Young | ... | Phil Loomis (as Cliff DeYoung) |
 | John Getz | ... | Michael Breyers |
 | Bernadette Peters | ... | Sarabeth Breyers |
 | Kathy Baker | ... | Anna Loomis |
| Mark Saul | ... | Dr. Steve Mostow |
| Amrapali Ambegaokar | ... | Intern Dani |
 | Terrance Christopher Jones | ... | Paramedic |
| Joy Osmanski | ... | Intern Lucy |
| Molly Kidder | ... | Dr. Megan Nowland |
| Jeffrey Dean Morgan | ... | Denny Duquette (uncredited) |
| Michael Sabulsky | ... | Orderly (uncredited) |
Season 5, Episode 2: Here Comes the Flood
9 October 2008Determined to reverse Seattle Grace's slide into mediocrity, the chief lays down some new rules for interns and residents with which no one's happy. Derek asks Meredith for further changes in her living arrangements. Lexie challenges Cristina's diagnosis for a patient with a persistent headache, and the chief's preoccupation with reputation blinds him to problems with the physical plant.
Season 5, Episode 3: Brave New World
16 October 2008Calllie worries over her first real date with Erica. Cristina stumbles upon a neglected area of the hospital.
Season 5, Episode 4: There's No 'I' in Team
23 October 2008Bailey's dream of a domino surgery is scuppered when one of the donors learns of her husband's affair, and Meredith is insulted when she gets no credit for the procedure she and Derek worked on together.
Season 5, Episode 5: Life During Wartime
30 October 2008The new trauma surgeon shocks everyone with his methods, Bailey is asked to save a girl with an inoperable tumor, and Callie's not sure what she wants.
Season 5, Episode 6: Rise Up
6 November 2008The residents and interns squabbling over procedures upsets Dr. Hunt, Erica discovers what happened to the heart she lost, and Derek asks Sloan to break out the McSteamy to distract Yang.
Season 5, Episode 7: These Ties That Bind
13 November 2008Izzie wrestles with her ghost, Torres uses a ground-breaking procedure to get her mind off of Hahn, and the interns continue teaching themselves spurred on by a new cohort.
