
| Charlie Sheen | ... | Charlie Harper (117 episodes, 2003-2008) |
 | Jon Cryer | ... | Alan Harper (117 episodes, 2003-2008) |

| Angus T. Jones | ... | Jake Harper / ... (117 episodes, 2003-2008) |
 | Conchata Ferrell | ... | Berta (85 episodes, 2003-2008) |
 | Holland Taylor | ... | Evelyn Harper / ... (60 episodes, 2003-2008) |
 | Marin Hinkle | ... | Judith Harper / ... (54 episodes, 2003-2008) |

| Melanie Lynskey | ... | Rose / ... (48 episodes, 2003-2008) |

| April Bowlby | ... | Kandi / ... (15 episodes, 2005-2007) |

| Jane Lynch | ... | Dr. Linda Freeman / ... (8 episodes, 2004-2008) |
 | Ryan Stiles | ... | Herb / ... (7 episodes, 2004-2008) |

| Emmanuelle Vaugier | ... | Mia (7 episodes, 2005-2008) |

| Robert Wagner | ... | Teddy (5 episodes, 2007-2008) |

| James Edson | ... | Stephan 'Bobby' Wasserstein (5 episodes, 2004-2006) |

| J.D. Walsh | ... | Gordon / ... (5 episodes, 2004-2006) |

| Ming-Na | ... | Linda Harris (4 episodes, 2007) |

| Rebecca McFarland | ... | Leanne (4 episodes, 2003-2007) |
 | Kris Iyer | ... | Dr. Prajneep (3 episodes, 2004-2007) |

| Jennifer Bini Taylor | ... | Nina / ... (3 episodes, 2003-2007) |

| Jenny McCarthy | ... | Courtney (3 episodes, 2007-2008) |

| Rachel Cannon | ... | Chloe / ... (2 episodes, 2006-2007) |

| Judy Greer | ... | Myra (2 episodes, 2007) |

| Sara Rue | ... | Naomi (2 episodes, 2006-2007) |

| Kimberly Quinn | ... | Donna (2 episodes, 2007-2008) |

| Nick Toth | ... | Football Announcer / ... (2 episodes, 2004-2005) |

| Robert Clotworthy | ... | Announcer / ... (2 episodes, 2006) |
 | Frankie J. Allison | ... | Rodney (2 episodes, 2003-2007) |

| Steven Tyler | ... | Himself (2 episodes, 2003-2006) |

| Denise Richards | ... | Lisa (2 episodes, 2003-2004) |

| Kelley West | ... | Amy / ... (2 episodes, 2004-2006) |

| Nicole Forester | ... | Camille / ... (2 episodes, 2004-2005) |

| Jodi Lyn O'Keefe | ... | Gail / ... (2 episodes, 2004-2005) |

| Jeri Ryan | ... | Sherri (2 episodes, 2004-2005) |

| Jenna Elfman | ... | Frankie (2 episodes, 2004) |

| Juliette Goglia | ... | Joanie (2 episodes, 2004) |

| Steve Tom | ... | Minister (2 episodes, 2005-2008) |
 | Katherine LaNasa | ... | Lydia (2 episodes, 2006) |

| Gail O'Grady | ... | Mandi (2 episodes, 2006) |

| Susan Blakely | ... | Angie (2 episodes, 2008) |

| Coby Ryan McLaughin | ... | Jeremy (2 episodes, 2008) |

| Carrie Reichenbach | ... | Alexis (2 episodes, 2008) |
|
| Lee Aronsohn | .... | executive producer (107 episodes, 2003-2007) |
| Mark Burg | .... | executive producer (100 episodes, 2003-2007) |
| Oren Koules | .... | executive producer (100 episodes, 2003-2007) |
| Chuck Lorre | .... | executive producer (100 episodes, 2003-2007) |
| Eric Tannenbaum | .... | executive producer (100 episodes, 2003-2007) |
| Kim Tannenbaum | .... | executive producer (100 episodes, 2003-2007) |
| Eddie Gorodetsky | .... | co-executive producer / consulting producer / ... (99 episodes, 2003-2007) |
| Mark Roberts | .... | co-executive producer / producer / ... (99 episodes, 2003-2007) |
| Don Foster | .... | co-executive producer (98 episodes, 2003-2007) |
| Susan Beavers | .... | co-executive producer / supervising producer / ... (97 episodes, 2003-2007) |
| Michael Collier | .... | producer / coordinating producer (78 episodes, 2004-2007) |
| Joe Bella | .... | co-producer (69 episodes, 2004-2007) |
| Toti Levine | .... | associate producer (68 episodes, 2004-2007) |
| Jim Patterson | .... | producer / co-producer / ... (58 episodes, 2005-2007) |
| Jeff Abugov | .... | co-executive producer (56 episodes, 2003-2005) |
| Mary T. Quigley | .... | co-producer (31 episodes, 2006-2007) |
| Eric Lapidus | .... | supervising producer (24 episodes, 2003-2004) |
| Tracey Ormandy | .... | producer (23 episodes, 2003-2004) |
| Sid Youngers | .... | supervising producer / consulting producer (22 episodes, 2004-2005) |
| Tatiana Nell | .... | coordinating producer (20 episodes, 2005-2006) |
| Andy Ackerman | .... | executive producer (8 episodes, 2003) |
| Steve Leff | .... | consulting producer (8 episodes, 2005) |
| Frank Merwald | .... | associate producer (4 episodes, 2003-2004) |
| Annette Sahakian Davis | .... | producer (1 episode, 2003) |
| Dan Foster | .... | co-executive producer (1 episode, 2006) |
| |
|
| Gabriel Solana | .... | makeup artist: Mr. Sheen (95 episodes, 2003-2007) |
| Janice Berridge | .... | makeup artist (62 episodes, 2004-2007) |
| Pixie Schwartz | .... | hair stylist (27 episodes, 2006-2007) |
| Ralph M. Abalos | .... | hair stylist (17 episodes, 2005-2006) |
| Robert Hallowell II | .... | hair stylist (16 episodes, 2003-2005) |
| Gabriella Pollino | .... | key hair stylist (12 episodes, 2006) |
| Gloria Ponce | .... | hair stylist (6 episodes, 2004-2005) |
| Ann Masterson | .... | makeup artist (4 episodes, 2003-2004) |
| Heba Thorisdottir | .... | personal makeup artist: Jenna Elfman (2 episodes, 2004) |
| Jennifer Guerrero | .... | hair stylist (1 episode, 2003) |
|
| Corey Jeen | .... | assistant makeup artist (unknown episodes) |
| |
|
| Mark K. Samuels | .... | first assistant director (72 episodes, 2003-2007) |
| Joseph Stafford | .... | second assistant director (49 episodes, 2005-2007) |
| Jean Sagal | .... | associate director (20 episodes, 2004-2007) |
| Lorri Fischer | .... | second assistant director (11 episodes, 2004-2005) |
| Christian Jensen | .... | second assistant director (11 episodes, 2007) |
| Carol Anne Miller | .... | second assistant director (5 episodes, 2003-2004) |
| Ellen Rosentreter | .... | day player second assistant director (3 episodes, 2006-2007) |
| Ron Moseley | .... | first assistant director (3 episodes, 2006) |
| Caryn Shick | .... | second assistant director (1 episode, 2003) |
| Dale White | .... | first assistant director (1 episode, 2003) |
| |
|
| Ron Arnold | .... | sound recordist (99 episodes, 2003-2007) |
| Bob La Masney | .... | sound re-recording mixer / re-recording mixer (73 episodes, 2003-2007) |
| Kathy Oldham | .... | sound re-recording mixer / re-recording mixer (72 episodes, 2003-2007) |
| Bruce Peters | .... | production sound mixer / sound mixer (72 episodes, 2003-2007) |
| Charlie McDaniel | .... | sound re-recording mixer / re-recording mixer (38 episodes, 2006-2007) |
| Michael Kreple | .... | foley mixer (11 episodes, 2007-2008) |
| Rick Partlow | .... | foley artist (5 episodes, 2005-2006) |
| Peter Damski | .... | production sound mixer (1 episode, 2003) |
| Tamara Johnson | .... | sound re-recording mixer (1 episode, 2003) |
|
| Dan Berlin | .... | sound utility (unknown episodes) |
| |
|
| Eric Lapidus | .... | executive consultant / creative consultant (68 episodes, 2004-2007) |
| Jean Sagal | .... | associate director / technical coordinator / ... (54 episodes, 2004-2007) |
| Marilyn Bagley | .... | script supervisor (52 episodes, 2003-2007) |
| Mona Garcea | .... | executive assistant (32 episodes, 2006-2007) |
| Ahmadu Garba | .... | assistant to writer (21 episodes, 2006) |
| Kathy Nawabi | .... | production coordinator (18 episodes, 2005-2007) |
| Adam Waring | .... | story editor (12 episodes, 2006-2007) |
| Allison Staak-Dettore | .... | production coordinator (8 episodes, 2004-2005) |
| Nicole Contreras Burla | .... | assistant to director (8 episodes, 2007-2008) |
| Traci Weintraub | .... | assistant to director (6 episodes, 2003) |
| Rick Beren | .... | technical coordinator / associate director (4 episodes, 2003-2004) |
| Susan Vercelli | .... | production coordinator (4 episodes, 2003-2004) |
| Susan Kesser | .... | publicist (2 episodes, 2007) |
| Carol McKechnie | .... | script supervisor (1 episode, 2003) |
| Mary Rodriquez | .... | production coordinator (1 episode, 2003) |
| Russ Sherman | .... | associate director / technical coordinator (1 episode, 2003) |
|
| Rhiannon O'Harra | .... | production assistant (unknown episodes, 2004) |
| Gary Mednick | .... | publicist (unknown episodes, 2005) |
| Tyrone Allen | .... | production assistant (unknown episodes) |
| Chad Cole | .... | assistant: Mark Burg and Oren Koules (unknown episodes) |
| Nicole Eberhardt | .... | assistant production coordinator (unknown episodes) |
| Fred Fein | .... | stand-in (unknown episodes) |
| Phil Gonzales | .... | publicist (unknown episodes) |
| Tiffany Moore | .... | production assistant (unknown episodes) |
| Alissa Neubauer | .... | script coordinator (unknown episodes) |
| Ben Sachs | .... | production assistant (unknown episodes) |
| Josh Stuart | .... | production assistant (unknown episodes) |
| |