Scott Bairstow was originally cast as the male lead , but was replaced by Eric Mabius soon after allegations of sexual assault on a minor were made against him in 2003 (he pleaded guilty to the lesser charge of second degree assault on 9 December 2003).
Although they are not displayed, all episode titles begin with the letter "L".
The opening title offers a variety of "L words" They are: - lunch - laughter - lashes - lure - legs - limber - literary - linger - lattes - life - learn - luxurious - long - looking - lap - Los Angeles - lullaby - labyrinth - lesbian - love - labels - liberty - lotion - lithe - lust - linger - lady - lickable? - libido - letting go - lips - liberal - lace - loft - lovely
The pregnancy of Tina Kennard in the show was filmed around the real-life pregnancy of actress Laurel Holloman.
Ossie Davis had a recurring role as the father of the Jennifer Beals's character. In the second season, Davis filmed scenes that showed his character becoming ill, then dying. Davis then died before his final episode was broadcast, so that episode was dedicated to him.
Shane (Katherine Moennig) is sometimes seen wearing a t-shirt with the word "GUSH". Leisha Hailey (Alice Pieszecki) is/was in a band called Gush.
This show was renewed for a second season one day after the pilot episode aired and it was renewed for a third season before the second season even began airing.
The photograph of a man's face hanging on the wall in the art gallery during the show's opening montage sequence is that of Vito Russo.
Season 3 episode 1 starts with a flash back of a woman group in 1973 and it shows two women, Marilyn and Teri making out. In the last episode of the season, the same Marilyn is the marriage commissioner that takes off with Peggy Peabody.