Brendan Fraser says he has no idea why Disney didn't offer him to reprise his role as George. He said he would've loved to do it again, but he made a commitment of performing in Looney Tunes: Back in Action (2003) as DJ Drake/Himself (Live-action) and Tazmanian Devil and Tazmanian She-Devil (Animation), so Christopher Showerman replaced Fraser in the role of George. Concidentally, "Back in Action" has an African setting of its own.In a 2022 interview with Entertainment Weekly, Fraser hinted that he didn't return because the studio didn't offer him enough money to come back. He said: "I think 'George' got a remake, and they built a joke into it that the studio was too cheap to hire me, which wasn't inaccurate."
For some unknown reason, Ursula's father Arthur Stanhope is neither seen nor mentioned in the movie.
Thomas Haden Church, John Cleese, Kelly Miracco (credited as Kelly Miller), Abdoulaye NGom and Keith Scott are the only actors to reprise their roles.
Lydell M. Cheshier also reprises his role as one of the guides, however his character name has been changes from Baleto to Bateke.
Lydell M. Cheshier also reprises his role as one of the guides, however his character name has been changes from Baleto to Bateke.
Thomas Haden Church reprises his role as Lyle Van de Groot.
Jordan Kerner: The movie's producer, from The Kerner Entertainment Company, is credited as the cameo Airline Passengers among with the others.
David Hoberman: The co-producer (for Mandeville Films) of the previous George of the Jungle (1997) film is credited as the cameo Airline Passengers among with the others.
Audrey Wells: The co-screenplay writer of the previous George of the Jungle (1997) film is credited as the cameo Airline Passengers among with the others.