Revealing mistakes: When Jack falls onto the ground clutching his head after Paul has fired off several shots into the dirt, you can briefly see an ear plug in Jack's ear.
Continuity: Christina crosses the street as traffic is stopped at a green light.
Factual errors: When Cristina Peck wants to give blood to help Paul Rivers, a nurse uses a blood collection system called Vacutainer to collect her blood. This system uses the power of vacuum to collect blood. To do this a vein has to be pricked with the needle and then a tube must be pricked too with the other side of the needle then the vacuum does the rest. In the film we see that the tube is already pricked to the needle, so it wouldn't work.
Crew or equipment visible: When Paul Rivers walks away after telling Jack Jordan to leave, the cameraman's shadow can be seen on the ground and bushes in front of him
Continuity: Months after the operation, after sleeping with Cristina, Paul still has a "hospital shave" on his chest.
Audio/visual unsynchronized: On one occasion when in Church, there is a close view of Jack, standing for a hymn. The audio is congregational singing. Jack is not singing, but the black guy to his right is singing enthusiastically, but not anything like what the rest of the church is singing,
Audio/visual unsynchronized: When Cristina is getting her car and tells the valet, "I don't need a fuckin' taxi," her lips do not move.
Factual errors: When Paul goes in for his heart transplant, a close-up shows a needle being used to give him an injection into an IV port. The IV port shown is a "needle-less" type and does not work with needled syringes.
Audio/visual unsynchronized: When the Private Investigator gives Paul the revolver, he flips it open to show that it is loaded. He then spins the cylinder and we hear a ratcheting sound. When a revolver is open, there is no ratchet mechanism connected to the cylinder...it rotates freely and silently.
Factual errors: When the doctor is listening to Paul's heart, he has his stethoscope in backwards. The ear pieces are supposed to face forward, but his are obviously facing backwards. In that position, not only would they hurt his ears, they would also hinder his ability to listen to the heart.
Errors made by characters (possibly deliberate errors by the filmmakers): A nickel weighs just under 5 grams so five nickels would be just under 25 grams
Continuity: When Christina Peck is in the hospital learning the fate of her husband and daughters, the doctor tells her that they all entered the hospital in critical condition. That would require them to have been transported to the hospital in an ambulance. In another scene, Marianne Jordan and Reverend John decide to drive past the scene of the accident to determine whether or not there were fatalities. On the street a body bag is visible. This would indicate that there was a death at the scene of the accident invalidating the doctor's statement that all three entered the hospital in critical condition.