The show is created using Adobe Photoshop images, animated using Adobe After Effects and edited using Apple's Final Cut Pro. Writing the script takes Dave Willis and Matt Maiellaro around four or five weeks, after which they spend a week making a rough show on video and get the voiceover work done. The animators use the QuickTime video as a reference and spend another five weeks making the finished 11 minute episodes. The whole thing costs around $60,000 per episode (an uncommonly low figure for an animated TV series).
When the teens move around, they make sounds according to the food that they are. Meatwad, for instance, makes a squishy sound. The creators actually bought eight pounds of hamburger meat and squished it with rubber gloves to get that sound. They also bought a milkshake and got some sounds from that too.
The picture of Doctor Weird's castle in New Jersey is actually taken from an episode of "The Real Adventures of Jonny Quest" (1996) called "Escape to Questworld". It's a shot of The Belle Isle Institute, where Dr. Jeremiah Surd is housed. The shot was originally the Himalayan outpost from the "Monster in the Monastery" episode of the 1964 series.
Frylock has a photo of himself and a young Dr. Weird on his bookshelf.
In the closing credits, the vocal sample is of Master Shake saying "Dancing is forbidden" (from the pilot episode).
The full versions of the puppet TV shows are hidden on the Volume 2 DVDs.
Schooly-D wrote the theme song on the same day it was recorded, while riding in a limo on his way to the studio to record the theme song. Dave Willis and Matt Maiellaro provided the backup vocals.
The Plutonian's ship is based on a villain named Uglor's ship from the Teen Force cartoon.
After the episode "Super Hero" (where Shake exposes himself to toxic/radioactive waste in an attempt to gain super powers), every time Master Shake throws an object to the ground, it explodes. Some past examples include a phone, a remote control, the chair, a toilet brush, and a losing lottery ticket. Shake even refers to this phenomenon in one episode.
The "Broodwich" episode is a direct tribute to indie animator Don Hertzfeldt, whose surreal comedy films were an influence on the show's creators.
Dave Willis and Matt Maiellaro created a pilot episode for a show called "Spacecataz", which featured two recurring villains from the Aqua Teens series: the Mooninites and the Plutonians. Though the show was never actually produced, the pilot episode was cut into several little parts and placed before Aqua Teen episodes during season four, taking the place of the "Dr. Weird" opening shorts for a while.
The mall in the first episode is taken straight from the pilot episode of "The Powerpuff Girls" (1998). It even says, "Powerpuff Mall" on the side of the building.
Through Seasons 1-3, when the show ended, the logo for Williams Street Studios was followed by the image of a skull and crossbones with the Cartoon Network logo as the skull's teeth. Over that would be the sound of Matt Maiellaro, the show's co-creator, shouting, "Skull!"
Emory and Oglethorpe, the Plutonians, share their names with two universities in Atlanta, GA. Williams Street - the company that produces the show - is based in Atlanta.
Carl has never addressed Frylock or Meatwad by their real names. If he addresses them at all, he always calls them "Fryman" and "Meatman" respectively.