Rene Russo's assistant "Annie" is portrayed by Robert De Niro's real-life adopted daughter Drena De Niro.
There was a scene that was filmed, but cut out to better explain how Mitch could take on Trey as his new partner. In the beginning the film, Mitch goes on an undercover sting with another cop. That was Mitch's partner. He was wounded during the shootout with Lazy Boy. In a scene that followed, Mitch is visiting his partner in the hospital who is in recovery and contemplating retirement.
While filming Mitch and Trey doing promos for Showtime, William Shatner complains that Mitch "is the worst actor I've ever seen". This is an obvious in-joke reference to the criticisms about William Shatner's notoriously "hammy" acting.
Despite the movie's title, premium cable broadcast rights to the movie were originally not owned by Showtime, but by HBO, under the same ownership as Warner Bros., the movie's distributor, as HBO has an output deal with them.
When William Shatner is teaching Trey (Eddie Murphy) how to act like a cop for TV, he demonstrates how to check if a bag of cocaine is real by dabbing his finger in the powder and tasting it on his tongue. In "Beverly Hills Cop", Murphy, in the role of Detective Axel Foley, finds a crate full of bags filled with cocaine and tests the drugs by using the same trick with his finger.