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It's a reference to Seymour Krelborn, a nerdy character from Little Shop of Horrors.
Wilkerson. The writers original wanted to keep the family's surname a mystery but it was already revealed on the show. The last name of the family has been revealed only twice in the show, in the pilot episode, where Francis wears the name tag "Wilkerson" on his school uniform (it can be seen best in the scene where he is talking with his family on the phone). Also, though unaired, it appears in a joke from the original pilot script. In that script, Malcolm was walking to school when a neighborhood kid came running up shouting, "Malcolm, Malcolm, Malcolm. I was talking to my parents last night - I was listening to them talk, and what's your last name?" "Wilkerson, why?" Malcolm replied. "Oh. Who are the Pariahs?" said the other kid. The joke was eventually cut. A special feature on the season 1 DVD stated also that their surname was Wilkerson. A trailer on the UK channel Sky One in Early 2006 advised you to spend time with "The Simpsons" and "The Wilkersons," advertising Sunday night new episodes of both series. Another trailer was released to advertise the last episodes, of 24 and Malcolm in the Middle, it claimed Say Goodbye to the Wilkersons. Also, in a certain episode at Hal's company picnic Hal is addressed as "Mr. Landon", but this was just a misunderstanding by his new boss, and Hal spends the remainder of the episode trying to work out how to tell his boss of his mistake. When Reese joins the army, his fake ID states that his surname is "Jetson", a reference to the 1960's TV show "The Jetsons". On Bryan Cranston's official website, Cranston says the crew regularly joked amongst themselves that their last name is actually Nolastname. During the series finale, when Malcolm is being introduced for his graduation speech, his last name is not heard due to feedback from the microphone. Just before Malcolm gives his graduation speech, Francis drops his employee ID on the ground and it clearly shows his name as "Francis Nolastname", a nod to the fact that the family surname has hardly been mentioned.
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