- Harvey Keitel replaced Dustin Hoffman in the role of Satan.
- A scene is shot in front of Tom's Restaurant in NY, the same restaurant used in "Seinfeld" (1990).
- Jon Lovitz is seen singing "Ladies Night". He sang the same song in another Adam Sandler film, The Wedding Singer (1998).
- Dana Carvey (Referee) broke his ankle while filming the Harlem Globetrotters basketball game scene, and ended up on crutches.
- Patricia Arquette didn't have to audition for the role of Valerie.
- Melanie Lynskey was considered for the role of Valerie Veran.
- Nicky's roommate has posters for Blowup (1966) and Psycho (1960) on the wall of his apartment.
- Carl Weathers from Adam Sandler's earlier film, Happy Gilmore (1996), re-appears here in a cameo, reprising his role of golf-pro Chubbs Peterson when Nicky arrives in heaven. The role is a continuity of the character's afterlife after dying in the previous film.
- Adrian's line "better to reign in Hell than serve in Heaven" is taken from the classic 17th century story, "Paradise Lost".
- The film features characters from Adam Sandler's CD "Stan And Judy's Kid" (Whitey the Referee [from sketch "Whitey"]; The Peeper [from sketch "The Peeper"]).
- Marilyn Manson was originally going to have a role in the movie but he later had to bow out due to conflicting schedules.
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: Nicky "dies" seven times in the movie.
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