| Matthew McConaughey | ... | Lt. Andrew Tyler, Executive Officer |
| Bill Paxton | ... | Lt. Cmdr. Mike Dahlgren |
| Harvey Keitel | ... | CPO Henry Klough |
| Jon Bon Jovi | ... | Lt. Pete Emmett, Chief Engineer |
| David Keith | ... | Maj. Matthew Coonan, USMC, Office of Naval Intelligence |
| Thomas Kretschmann | ... | Capt.-Lt. Gunther Wassner |
| Jake Weber | ... | Lt. Hirsch, USNR |
| Jack Noseworthy | ... | Seaman Bill Wentz, Radioman |
 | Tom Guiry | ... | Seaman Ted 'Trigger' Fitzgerald, Radioman |
| Will Estes | ... | Seaman Ronald 'Rabbit' Parker, Torpedoman |
| Terrence 'T.C.' Carson | ... | Steward Eddie Carson |
| Erik Palladino | ... | Seaman Anthony Mazzola, Planesman |
| Dave Power | ... | Seaman Charles 'Tank' Clemens, Machinist Mate |
| Derk Cheetwood | ... | Seaman Herb Griggs, Helmsman |
| Matthew Settle | ... | Ens. Keith Larson, Chief Torpedoman |
| Rebecca Tilney | ... | Mrs. Dahlgren |
| Carolyna De Laurentiis | ... | Prudence Dahlgren |
| Dina De Laurentiis | ... | Louise Dahlgren |
| Burnell Tucker | ... | Adm. Duke |
| Rob Allyn | ... | Ensign |
| Carsten Voigt | ... | German Chief Hans |
| Gunter Würger | ... | Lt. Kohn, German Executive Officer |
| Oliver Stokowski | ... | German E-Chief |
| Arnd Klawitter | ... | German Hydrophone Operator |
| Kai Maurer | ... | German Planesman |
| Robert Lahoda | ... | German Engineer |
| Peter Stark | ... | German Lookout |
| Erich Redman | ... | German Bosun |
| Sergeant William John Evans | ... | Marine Sergeant |
| Robin Askwith | ... | British Seaman |
| Jasper Wood | ... | Petty Officer |
| Martin Glade | ... | Gunner Officer |
| Oliver Osthus | ... | Depth Charge Officer |
| Corporal John William Falconer | ... | Other Sergeant |
| Corporal Cory Glen Mathews | ... | Other Sergeant |
| Valentina Ardeatini | ... | Mrs. Peggy Larson |
| rest of cast listed alphabetically: |
| Norman Campbell Rees | ... | Military police seargent (uncredited) |
