The producers, creators and writers of All That (1994) decided to give Kenan and Kel their own show after noticing how much chemistry there was between the two teenagers.
Kenan's sister is rarely seen in the later episodes. This was because Vanessa Baden (Kyra) was attending school.
The character's name Marc Cram is a palindrome, which means it is spelled and pronounced the same backwards.
The creators/writers of "Kenan & Kel", Dan Schneider, Brian Robbins and Dan Frischman, who plays Chris Potter, met while starring on the TV show Head of the Class (1986). The three still remain close friends.
Kenan Thompson does an impression of Bill Cosby on occasion in the series. Years later when Thompson joined the cast of Saturday Night Live (1975), he would also do impressions of Cosby on that series as well.