- The date when Helen drinks the potion (October 26, 1985) is the "present" date in Back to the Future (1985), also directed by Robert Zemeckis.
- In the scene where Helen sits down onto a shovel handle, she didn't sit in the way she was expected to do, so the SFX people had to morph the image to make it look like the shovel handle was pushing up into her chest.
- Meryl Streep accidentally scarred Goldie Hawn's cheek with a shovel during the fight scene.
- Director Trademark: [Robert Zemeckis] [citation] The shots in the psychiatric clinic where Helen is brought look exactly like those in One Flew Over the Cuckoo's Nest (1975).
- Catherine Bell was Isabella Rossellini's nude body double.
- In the scene where Madeline punches in the entrance code and enters the gate as Helen slips past her unseen, you get a brief glimpse of her license plate. It reads "2HYE305", not "ZHEMEKIS" as previously noted
- A pneumatic bra was built to create the effect where Meryl Streep's breasts become higher and firmer after drinking the potion, but the effect didn't look realistic enough. In order to get the shot Meryl Streep's dresser stood behind her, out of sight of the camera, and pushed her breasts into position.
- An edited picture from the original ending was used during Ernest's funeral scene. The picture of him aged was actually a of him in full age makeup from the first ending. 'Bruce Willis (I)''s aged face was used, but put on an actual picture of a mountain climber, which thus resulted in the end picture of Ernest at his funeral.
- During the description of the plot to kill Madeline, there was a quick shot of the folder being stamped "case closed" at a desk. Also on the desk was a brain in a glass jar labeled "abnormal" - a tribute to the original Frankenstein.
- Bruce Willis replaced Kevin Kline as Ernest.
- In an interview Meryl Streep revealed that she assumed the role of Helen (Goldie Hawn's character) was meant for her. Not the "song-and-dance" role of Madeline.
- The three main character's names are a play on words. Madeline, Ernest and Helen can be shortened to Mad, Ern, Hel, or "Madder 'n Hell."
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: There are two scenes (both involving Ernest Menville) that foreshadow Madeline Ashton's and Helen Sharp's fall down the stairs outside Ernest's memorial - when Ernest pushes Madeline down the stairs during the fight that ensued after she took the potion and when Ernest argues against taking Lisle Von Rhuman's potion by speculating what would happen if he were "pushed", rather "fell", down the stairs. Their fall outside his memorial can be interpreted as his revenge against them for for their treatment of him in their ongoing battle with each other and for using him as a tool in their pursuit of everlasting youth and beauty.
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