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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- The quirky cases of a former model and a smart aleck detective who manage a private detective agency.
- A seemingly timid but secretly ruthless ingénue insinuates herself into the lives of an aging Broadway star and her circle of theater friends.
- The Korean War M*A*S*H unit veteran operates as Chief Surgeon in a major city hospital with his colleagues.
- The tragic life of a self-destructive female rock star who struggles to deal with the constant pressures of her career and the demands of her ruthless business manager.
- When billionaire Jean-Marc Clement learns that he is to be satirized in an off-Broadway revue, he passes himself off as an actor playing him in order to get closer to the beautiful star of the show, Amanda Dell.
- Frustrated housewife/writer Cathy Palmer ghostwrites a story about Rebecca Ryan, a dashing international spy, and wins a trip to Paris. While there, she is involved in an accident, and awakens in the hospital believing she IS Rebecca Ryan. Much craziness ensues as she meets the writer of the Rebecca Ryan books, thwarts real international spies, and eventually gets her memory back.
- Ken McLaughlin struggles to please his family in any way. He comes back from boarding school boasting poor grades and facing going through the fifth grade again, much to his fathers dismay. Ken's mother, Nell, manages to persuade his father Rob to let him choose a colt from the herd for himself. He instead chooses a sorrel chestnut filly, who becomes injured soon after. Can Ken nurse the filly back to full health?
- 1977–19871h 30mTV-G6.6 (166)TV EpisodeStanley and Joyce Adams are nervous newlyweds. Leonora and Ernie Klopman meet widowed tailor Morris Beekman and happy spinster Mae Allen. Merrill demands that Julie seat Cleo Bagby at his table, but she's Gopher's girl and a stowaway.
- Maddie Hayes wakes up to find her staff have quit and all her money has been stolen. One of her few remaining assets is a loss-making investigation agency run by David Addison. She sacks the staff but David is determined to keep it going.
- House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- The team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- A nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.