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- Enrique (Christopher De Leon), a compassionate doctor who does probo no work most of the time. But the character's innate generosity and close relationship with his patients have become a bone of contention between him and his family especially with his jealous wife. What happens if a man comes into conflict with his personal convictions, love for his family, and dedication to his medical practice?
- They're a common sight at the country's docks and piers, embarking on large ships and boats for the pleasure of the crew and a quick buck. There's even a name for them - "mariposang dagat" or "butterflies of the sea" - a poetic name that signifies the way that they flit from ship to ship. But the name hides the tragic and difficult nature of their lives. Donna (Jodi Sta. Maria) is a young woman who becomes a "mariposang dagat" through the influence of her abusive adoptive mother Magdalena (Snooky Serna), herself a prostitute. Can Donna Lee escape the life that Magdalena leads her to? Will the basic fact that she is both innocent and unlearned work against her in her journey? And will motherhood take her out of this dead end life?
- An inspiring story of a woman who goes through a painful journey of finding her fulfillment as a wife, a mother, and as a person. Balancing her time between her career and family was rather difficult for Daisy. But things even became more complicated when her eldest daughter April was afflicted with Cerebral Palsy and needs all the love, care and attention only a mother can give not knowing that her other daughter Con-con was jealous of the attention she get from Daisy. But the drama escalates when Daisy discovered that April is sick and have a few months to live.
- Dodong (Jiro Manio) and Nitoy (Carlo Aquino) are brothers who live without proper care and guidance from their parents. As a young boy, Dodong feels that he's different from his brother. He is gay. Despite the sexuality, his brother Nitoy, loves him so much. They've been through a lot in life especially when Nitoy loses sanity. To support his brother's medication, Dodong enters gay prostitution. He gets beaten up all the time by his customers but prostitution is the only way he knows how to survive and help Nitoy.
- An old maid dreaming of her prince charming to come.
- The story of Margarita (Gretchen Barretto) forced to work off her sweat for her family while her good-for-nothing husband stays happily unemployed most of the time. Eventually though, she finds a good-paying job through the help of the town Mayor (Phillip Salvador) who becomes her good friend, and much later, her lover. Is it wrong for Margarita to fall for someone who can fulfill her needs for her family and as a woman? How can she stay faithful if the man she married does nothing but run away from his responsibilities?
- Jun-Jun, Tata and Jepoy left their beloved parents back in Agusan del Sur to earn enough money to pay for their family's mounting bills and help with their father's medical needs. Sadly, their dreams of a prosperous life lead them to an illegal recruiter, who "sells" them to become virtual slaves to abusive masters. But the biggest problem for the brothers is that the recruiter also separated them - a tragedy, considering that they had never been apart their whole lives. Jun-Jun, the youngest and most daring of the brothers, hatch a plan to escape from his employer and look for his brothers but he was imprisoned.With the help of Father Cosme, Jun-Jun started to look for his brothers and was eventually reunited with Tata but they were still looking for their brother Jepoy.
- What happens when two lovers discover that their families are entangled in a web of illicit passion? For Emil and Dana, the supposed sweet love of their youth turns into trauma when they discover that Dana's mother is the mistress of Emil's father. As this revelation dawns on them one tragic day, Emil and Dana are yet to find out if their young love can weather their cruel circumstances.
- Ramon grew up in a poor community in Bicol and was abandoned by his father at an early age. From the province, he went to Manila hoping to give his family a better future and to be able to finish his studies. One day, his professor encouraged him to try Karate to earn a scholarship. His hard work paid off when a Singaporean Kyokushin Karate trainer, Sensei Steven (Atoy Co), discovered him and helped him finish high school and become a Karate champion. As his dreams slowly turned to his favor, another setback arose when his girlfriend got pregnant and eventually betrayed him. How did he survive after all of the challenges in his life? What inspired him to enter the MMA scene?
- Life has always been hard for Victorio, who became a construction worker at the age of 12 to help his sickly father and their family survive. He always had close brushes with the authorities for drug-dealing but eventually gets caught and jailed. Because of this, his father Nitoy's (Ronnie Lazaro) heart is broken by his son's troubles and is left to fend for himself amid failing health. This leaves Victorio's despairing and depressed while inside the prison. He gets initiated into a gang and beaten by fellow inmates. He also gets brutally coerced by authorities to give up the names of his drug-dealing comrades but keeps his mouth shut for fear of his family's fate outside. Victorio soon finds enlightenment and discovers a way to continue studies while inside prison. After studying for two years, he is released for being one of the topnotch high school graduates in the city, and eventually offered a scholarship in the Quezon City Polytechnic University. How did Victorio survive prison? Can someone really change for the better despite their circumstances?
- Judith (Maymay) and her family suffered from discrimination all their lives. But when the opportunity to be the Aeta tribe's representative at the "Mutya ng Biaan" came, Judith discovered a strength she never knew she had. Her parents Jocelyn (Mercedes Cabral) and Henry (Nyoy Volante), who both cannot read and write, taught her to put education above everything. Her sister April (Mara Lopez) even sacrificed her own education so they can afford to send Judith to school. One day, April got invited to join the "Mutya ng Biaan" pageant to represent their Aeta community for the first time. When Judith saw the acceptance and support given by other people for her sister, she felt motivated to follow in April's footsteps. Upon Jocelyn's advise, Judith decided to prioritize her studies and even moved to the city of Balanga, Bataan to do this. Unfortunately, she would skip school because of the discrimination she once more faced from the locals. Judith would soon find out how much sacrifice her entire family made because they had hoped so much for her future. Soon, her father became ill. Worried because her family had no means to pay for his medicine, Judith decided to stop studying and worked at a shoe factory. Judith's life would soon change when she got invited to join the "Mutya ng Biaan." She now saw this as an opportunity to help her family financially, help her get an education, and get the recognition she and her community needed. Defying her own mother's wishes, Judith remained firm with her decision. Judith won the "Mutya ng Biaan," and ranked ninth in the "Mutya ng Mariveles" 2019. She used her prize money to provide food for that her fellow Aetas never had the luxury to have. Even after being a beauty queen, Judith still plans to finish her studies.
- Anna (Nikki) struggled to have a perfect family life, being abandoned and adopted as a G.I. baby. She was taken in by Mama Rossie (Ruby Ruiz), an active member of the church. Eventually, they settled down in Anak Bayan, Paco, Manila where she met her cousin, June (Joross) whom she fell in love with and married. Soon, the couple bore a first-born with autism, John Paul (JM Ibanez). With a second child on the way, they hoped their second child would be different from the first one. But Joshua (Simon Pineda), their second son, turned out to have the same condition. Eventually, the couple had a third child, Judith (Miel De Leon). This time, she was born without autism. Having two children with autism turned out to be difficult for the newlyweds. Anna fought for her children as June lost his way to infidelity. Anna protected her two sons, John Paul and Joshua from society's judgmental eyes, while June soon tried to be the father and partner for their struggling family. Later on, Anna and June's unconditional love for their family prevails.The couple is now part of the Servants of Charity, mostly a community of abandoned Filipino children with autism. Anna and June have embraced their true calling and become volunteers and motivational speakers on building a family full of understanding and acceptance for people with autism and special needs.
- Bryan Tagarao (Awra Briguela) struggled throughout his childhood but always fought through with humor and grace. Even though teased as ugly and for being gay, his beautiful persona shone through. The Cagayan de Oro native had a hard time fitting in, even though he comes from a family of comedians. At home, life was taken very seriously. His father Romeo (Bembol Roco), prevented him from being openly gay. Bryan was bullied so much for being gay and different, but he showed that he was more than his friends characterized him. He gave up his own education so he could help his family, and eventually became the breadwinner, selling corn and burgers, and working as a janitor. As an adolescent, Bryan struggled even more with trying to appear more "manly" for his family to make his family proud of him. But he fought his insecurities and became Boy Band PH's personal assistant. At 21, Bryan came out and decided to embrace his gender identity. When he learned how to cross-dress, "Brenda Mage" was born. As Brenda, he got acting jobs in indie films and became an entertainer in Japan. He also started vlogging, earning better money for his family. Brenda started earning bigger when he was invited to perform at comedy bars. His family have been supportive, especially his mother, and he has gained the respect of his father in the process. Eventually, Bryan was crowned "It's Showtime's" Miss Q and A InterTALAKtik and reigned even more in her personal and professional life. Bryan showed that no matter how society treated one unfairly, one must stay strong to achieve one's dreams.
- RJ (Jameson Blake) grows up in Brunei with his doting aunt and adoptive mother, Vivian, played by Optimum Star Claudine Baretto in her latest TV comeback. With Vivian's full support, he pursues dancing and hones his craft when the two come home to the Philippines. Seeing how dedicated RJ is, Vivian pushes him to reach his goals. But while he begins to dream of being a professional dancer and well-known Dancesport competitor, RJ gets diagnosed with Guillain-Barré Syndrome (GBS), a rare neurological disorder which causes progressive paralysis, starting from the feet and progressing up throughout the rest of the affected person's body. RJ battles with the disease for almost a year and the two almost give up on their dreams. But Vivian sees RJ fighting in spite of his physical limitations. Eight months later, RJ recovers from GBS and makes it to numerous local and international Dancesport competitions, which leads to a bittersweet reunion with his biological parents, Maya and Robert. Soon, the two try to take RJ back from Vivian because of his newfound glory. But RJ chooses to stay with Vivian, the only person he has considered to be his real family.
- Despite being poor and unable to finish his studies, Dong (Empoy Marquez) has always persevered in life. He became a taho vendor at the University of the Philippines at Diliman, QC, where he was a hit with students and academicians because of his positivity and light-hearted manner. After a 10-year relationship, 44-year-old Dong meets and falls in love with the 22-year-old Catherine (Jennica Garcia). Their May-December love affair causes a rift between their own families. Dong fights for their relationship and even treats Catherine's daughter from her previous relationship, as his own. He eventually earns the respect and approval of his wife's relatives through his genuine care for Catherine's family. Catherine gets an opportunity to work in Bahrain as a domestic helper and decides to take it, to Dong's frustration. She said it will help in their finances and help their other two kids go to school. Upon the departure of his wife, Dong becomes weak physically and emotionally. He becomes quiet and stops being the funny father he used to be because he misses his better half so much. His body eventually gives up and is diagnosed with a lung disease. Dong pursues selling taho because he wants all of their children to get the education he and his wife were not able to attain. Aurain (Heaven Peralejo) their eldest, convinces his father she would stop going to school to help out the family. For awhile she is able to help until she gets pregnant. Despite this, Dong uses his sense of humor to lighten up his family's mood, and saves enough money for his two other bright children's education. Dong and Catherine, although apart, hope for the future of their family.
- Carol (Maris) and Erlwin's (McCoy) love for music make them instant friends. However, their time together is cut short after Erlwin returns to their province. But distance does not hinder them from developing feelings for each other as they exchange letters for eight years, maintaining the relationship they have built. Years pass and they decide to meet again, but Erlwin does not make it in time to meet Carol. In pain, Carol vows to forget her feelings for Erlwin and moves on with her life. After several years, Carol meets a man whom she falls in love with, and they decide to get married. But as their wedding day nears, Carol crosses path with Erlwin. Their encounter brings back Carol's feelings for her old fling, which tests her love for and faithfulness to her fiancé. Where will Carol and Erlwin's reunion lead to? How will they prove they are destined for each other?
- Growing up poor, Diana (Pokwang) desires to finish her studies to give her family a bright future. But her parents think otherwise, believing marrying a man from a family of farmers would give her a comfortable life. This pushed Diana to leave her family and try her luck in Manila where she worked as a helper. Her employers instantly noticed her dedication and helped her finish college. She eventually landed a job in the municipal office, which helped her provide for her parents in the province. She then met Victor, the man whom she fell for and became her husband. However, the man she thought would complete her life was also the one who would destroy her dreams for her family as Victor became an alcoholic and constantly hurt their children. Will Diana be able to pull through from this obstacle?
- Nena (Irma Adlawan) is admired in her community for her dedication as a teacher for 32 years. She eventually decides to retire and put up her own business to spend more time with her family. However, her dream of having a better life is instantly taken away after her business partner takes all the money she has. On the verge of giving up, she finds a high paying job as a caregiver in the US, hoping to regain everything she lost. But things do not go as planned as Nena learns that the person who recruits her is a human trafficker and forces her to work as a house help for an abusive Filipino family. She gets maltreated, is underpaid, and even made to sleep with the dogs by her employers, putting her in constant misery. Determined to escape her horrible situation, she then meets a young American boy who she hopes could be her way to finally break free from her ill-fated life. How will Nena survive the life she is in?
- Melvin (Enchong) grows up longing for attention from his parents, who devote most of their time taking care of his brother Michael (Zaijian Jaranilla) who has cerebral palsy. The lack of affection fosters bitterness in him, which makes him promise to shower love to his future family, unlike how he is treated by his parents. However, Melvin's dream of a perfect family is shattered as a series of adversities hits his life and forces him to choose between his family and marriage. Melvin is first tested when his father becomes severely ill, while his wife is going through a tough pregnancy. He goes on to face a tougher battle after his child is diagnosed with autism, and he unexpectedly has to take care of his sick brother while his mother recovers from a kidney operation. All of the chaos takes a toll on Melvin's marriage as his wife feels that he has failed as a father to his children with all the time he spends to help his family. As if life could not get any harder, Melvin's father and brother pass away. How will Melvin rise above the chaos that surrounds him?
- Ryan (Zanjoe Marudo) hails from a poor family, but this does not stop him from finishing school with the help of his loving father Ramon (Joey Marquez). He perseveres and becomes a public school teacher, and vows to help the kids in his community get the education he was fortunate to have. However, one major hindrance to his goal is their barrio's location-it is separated from the town by a river, making it difficult for the kids to attend school. This pushes Ryan to build a raft he calls "Balsa Basa" where he can teach kids. Despite his pure intentions, many cast doubts on his plans, with some parents worrying for the safety of their children. His own father even discourages him and tells him to stop his ambition. But a bigger turmoil will shake his determination as a strong typhoon hits them while sailing in the middle of the river, putting him and his students' life in danger. This will ignite a stronger crusade to end his passion project. How will Ryan fight for his goals?
- Teba (Janice de Belen) dismisses young Ian's (Enzo Pelojero) wish to become a soldier, thinking that it is merely a kid's dream. When her son grows up, Teba starts to worry about his dedication to engage in the dangerous profession. Despite her motherly concerns, Teba allows Ian (Joshua Garcia) to pursue his dream. However, she soon finds out that her son sustained a horrible wound while trying to win the war against rebel forces in the Zamboanga siege. As Ian succumbs to his injuries, Teba experiences the jolting pain of having to bury her beloved son.
- Jenny (Vivoree Esclito) promises her mother Elisa (Valerie Concepcion) that she will never rush into a relationship. Her first encounter with Janluis (Charles Kieron) starts to make her eat her words. Because of her admiration for Janluis, Jenny goes to great lengths in hopes of capturing his attention. However, Jenny continues to experience disappointments despite the numerous times that she forgives Janluis throughout their relationship. Jenny feels ready to give up, but soon gets a reminder that true love is worth every painful moment.
- Peachie (Jolina Magdangal) struggles to find the true purpose of her supernatural ability.
- Marrz Balaoro (Ann Curtis) fights through the challenges in his life in order to celebrate himself as a transgender man.
- UAAP Season 81 women's volleyball tournament Most Valuable Player Cherry Ann 'Sisi' Rondina strives to achieve victory for herself, her family, and her beloved university.