- Mother, with husband Ryan Piers Williams, of son Sebastian Piers Williams (b. May 29, 2018) and daughter Lucia Marisol Williams (b. May 4, 2020).
- Parents are Honduran.
- Is the youngest person to win an Emmy for Lead Actress in a Comedy Series. She won the award at age 23.
- Lloyd's of London has insured America's smile for $U10 million.
- During an interview with her The Sisterhood of the Traveling Pants (2005) co-star Alexis Bledel for Latina Magazine, she was stunned to discover that Alexis speaks Spanish and had throughout production of the film.
- Is the youngest of 6 siblings.
- (June 27, 2011) Married her boyfriend of 6 years Ryan Piers Williams following a year-long engagement.
- She has the same first name as her mother.
- Attended the University of Southern California where she studied International Relations.
- Started acting in community theater and school plays at the age of eight.
- One of People Magazine's 100 Most Beautiful People. (2009)
- One of Time magazine's 50 Most Influential People in 2006.
- Starring and playing the lead role in ABC's Ugly Betty (2006) (aka "Betty La Fea" - USA) as "Betty Suarez". It's a modern tale of the ugly duckling fairy tale. (September 2006)
- She has appeared in one film that has been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Real Women Have Curves (2002).
- Was allegedly cast in the lead role in An Invisible Sign (2010), but was replaced by Jessica Alba before filming began.
- Two of her films, Lords of Dogtown (2005) and The Sisterhood of the Traveling Pants (2005), opened in the United States on the same day: Friday, June 3, 2005.
- Went to Calabash Elementary School in the San Fernando Valley from 1994-1995 where she played one of the lead characters in her 5th grade graduation play called "Oliver." She played the "Artful Dodger" in the production.
- Playing "CB's Sister" in the Off-Broadway play, "Dog Sees God: Confessions of a Teenage Blockhead", at the Century Center for the Performing Arts (New York, NY). (December 2005)
- Ranked #84 on the Maxim magazine Hot 100 of 2008 list.
- Shooting for The Sisterhood of the Traveling Pants 2 (2008). (2007)
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