- Maggie Smith refused to appear on Broadway in "Lettice and Lovage" unless Tyzack was also allowed to join the cast by Actors Equity, arguing that their chemistry and Ms. Tyzack's gifts fulfilled the requirement of singularity.
- Although she played Antonia Minor, the niece of the first Roman Emperor Augustus who was 27 years her senior, in I, Claudius (1976), she was more than six years older than Brian Blessed, who played Augustus.
- She was awarded a Laurence Oliver Theatre Award in 1982 (1981 season) for Best Actress in a Revival, Who's Afraid of Virginia Woolf?
- Tyzack was awarded the OBE (Officer of the Order of the British Empire) in the 1970 Queen's Birthday Honours List for her services to drama. She was elevated to CBE (Commander of the Order of the British Empire) in the 2010 Queen's New Year Honours List for her services to drama.
- Began her professional career in the early 1950s at a repertory company in central England, where for two years she performed in a play a week, for almost 50 weeks a year.
- Joining the Royal Shakespeare Company in 1962, Margaret was known for her regal stance and added a gallery of queens to her credits over the years, including Queen Anne, Queen Mary and Queen Elizabeth II.
- Won Broadway's 1990 Tony Award as Best Actress (Featured Role - Play) for "Lettice and Lovage." She had previously been nominated for a Tony in the same category in 1983 for Shakespeare's "All's Well That Ends Well."
- Educated at (and later an associate member of) the Royal Academy of Dramatic Arts after attending St Angela's Ursuline School, then a convent school outside London.
- Was Emmy-nominated for Best Dramatic Actress (Limited Episodes) in 1972 for her title performance in "Cousin Bette" on Masterpiece Theatre. She lost out to Susan Hampshire for her portrayal of Becky Sharp in "Vanity Fair."
- Played Oenone to Helen Mirren's Phedre at the National Theatre on London's South Bank. This production of Phedre also toured to Epidaurus, Greece on 10 & 11 July, 2009 and was in Washington DC, USA, 17 - 26 September 2009.
- Grew up in Greater London (formerly West Ham) and attended the all-girls St Angela's Ursuline School in Newham.
- Appeared as Mrs St Maugham in the Chalk Garden at the Donmar Warehouse theatre in London, alongside Penelope Wilton and Felicity Jones.
- Tyzack was the daughter of Doris (née Moseley) and Thomas Edward Tyzack. Her husband, Alan Stephenson, was a mathematics professor. They had a son, Matthew Stephenson (born 1964).
- Received both the Olivier and Evening Standard Drama best actress award for 'The Chalk Garden'.
- Her husband was a lecturer.
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