Blonde, green-eyed Lucille studied diction under
René Simon at the Cours Simon drama school in Paris and acting under thespian and theatrical director
Charles Dullin. She began on the stage in plays by Molière and Achard and later toured the French islands of Martinique and Guadeloupe with a troupe led by
Jean Gosselin. Having made her movie debut in 1953, Lucille's first major role was as appliance store saleswoman Rita, one of
The Good Time Girls (1960), in
Claude Chabrol's classic Nouvelle Vague comedy drama about the romantic adventures of four young Parisiennes. She then co-starred opposite
Christian Marquand in
Henri Decoin's romantic comedy
Tendre et violente Elisabeth (1960) and had a supporting role as
Mel Ferrer's intended bride in the Franco-British horror film
The Hands of Orlac (1960).
Lucille Saint-Simon retired from acting in 1965 after a mere thirteen film appearances. Her first husband was the Swiss actor
Jacques Verlier. They divorced after six years. Their daughter,
Karina Verlier (née Stämpfli) is also an actress. Lucille later married the actor
Georges Rivière.