- Famous among Star Trek sequel fans for his portrayal of Chancellor Gowron, supreme leader of the Klingon Empire.
- "Duras!" and "Gowron!" (O'Reilly's character Klingon Chancellor Gowron and his enemy Duras; from The Next Generation and Deep Space Nine) are quoted when clicking on the Protoss Carrier unit in the computer game "StarCraft".
- Has made guest appearances on two different series in which one of the main characters was a shapeshifter: Manimal (1983) and Star Trek: Deep Space Nine (1993).
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