At the time of her death, she was one of the last surviving stars from the Golden Age of Mexican Cinema.
She studied at the Theater School of the National Institute of Fine Arts and was a student of the "father of Mexican theater" Seki Sano, which forged her for a fruitful career on stage.
She also jointly holds the record, with Isela Vega, for the most Ariel Award for Best Supporting Actress wins, with three; with a further three nominations.
Murguía holds the record for the most nominations for the Ariel Award for Best Actress without a win, having been nominated a total of five times.
Although she had very few leading roles in her very long career, the quality of her acting work, in addition to her simplicity, made her one of the most recognized actresses in Mexican cinema.
She was a Mexican film and television actress .
In later years, she was best known for voicing Mamá Coco in the 2017 Disney-Pixar animated movie Coco.
Murguía was honored with the special Ariel de Oro award for lifetime achievement in 2011.
She worked with the most important directors in key films of Mexican national cinematography of the last three decades of the 20th century.
In 2004 she won the Mayahuel de Plata Award (Guadalajara Film Festival) for her career.