- About California... "I thought it was an appalling place. Then I went through a period of being amused by it. Now it's sort of both. Californians don't have that marvelous British cynicism, but then the British can be so patronizing at times".
- On her nude scenes: "I didn't have any qualms. I'm used to taking my clothes off in front of strangers. I've done it since I was 14 - with my mother's adult education art classes. She liked to paint and I went along as a life model."
- It's funny. I'm now in a more senior position and yet those feelings of sheer utter excitement of going to work just don't exist any more. - on ER (1994)
- "Certainly, since Anthony Edwards left ER (1994), I would say that my work on the show has diminished in terms of the challenges I face as an actress and what I am getting to do creatively on the show. If it continues to be diminished, then I am not going to be very happy".
- I do get annoyed with myself. I wish I was more focused and pushy as an actress. I suppose I should be out there more saying, "I want to do this role" or "Get me seen by this person." But that's just not me.
- On playing Dr. River Song in the Doctor Who (2005) episodes "Silence in the Library" and "Forest of the Dead": I've always wanted to be like Sigourney Weaver in Alien (1979); this is probably as close as I'll get.
- Like all women, there are things that I don't like. My butt's heading closer to the ground every year, and I'm not overjoyed about that.
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