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- DirectorElia KazanStarsVivien LeighMarlon BrandoKim HunterDisturbed Blanche DuBois moves in with her sister in New Orleans and is tormented by her brutish brother-in-law while her reality crumbles around her.
- DirectorMilos FormanStarsJack NicholsonLouise FletcherMichael BerrymanIn the Fall of 1963, a Korean War veteran and criminal pleads insanity and is admitted to a mental institution, where he rallies up the scared patients against the tyrannical nurse.
- StarsJoanne WoodwardSally FieldBrad DavisA young woman whose childhood was so harrowing to her that she developed sixteen different personalities is treated by a doctor.
- DirectorJoseph SargentStarsJessica LangeTammy BlanchardRon WhiteA true story of a young woman whose abusive childhood results in her developing a multiple personality disorder.
- DirectorGraeme CliffordStarsJessica LangeJonathan BanksBonnie BartlettThe story of Frances Farmer's meteoric rise to fame in Hollywood and the tragic turn her life took when she was blacklisted.
- DirectorJean-Jacques BeineixStarsJean-Hugues AngladeBéatrice DalleGérard DarmonA lackadaisical handyman and aspiring novelist tries to support his younger girlfriend as she slowly succumbs to madness.
- DirectorGus Van SantStarsRobin WilliamsMatt DamonBen AffleckWill Hunting, a janitor at M.I.T., has a gift for mathematics, but needs help from a psychologist to find direction in his life.
- DirectorBarbra StreisandStarsBarbra StreisandNick NolteBlythe DannerA troubled man talks to his suicidal sister's psychiatrist about their family history and falls in love with her in the process.
- DirectorRon HowardStarsRussell CroweEd HarrisJennifer ConnellyA mathematical genius, John Nash made an astonishing discovery early in his career and stood on the brink of international acclaim. But the handsome and arrogant Nash soon found himself on a harrowing journey of self-discovery.
- DirectorSteven SoderberghStarsRooney MaraChanning TatumJude LawA young woman's world unravels when a drug prescribed by her psychiatrist has unexpected side effects.
- DirectorStephen DaldryStarsMeryl StreepNicole KidmanJulianne MooreThe story of how the novel "Mrs. Dalloway" affects three generations of women, all of whom, in one way or another, have had to deal with suicide in their lives.
- DirectorLars von TrierStarsKirsten DunstCharlotte GainsbourgKiefer SutherlandTwo sisters find their already strained relationship challenged as a mysterious new planet threatens to collide with Earth.
- DirectorWoody AllenStarsCate BlanchettAlec BaldwinPeter SarsgaardA New York socialite, deeply troubled and in denial, arrives in San Francisco to impose upon her sister. She looks like a million dollars but isn't bringing money, peace or love.
- DirectorGavin O'ConnorStarsBen AffleckAnna KendrickJ.K. SimmonsAs a math savant uncooks the books for a new client, the Treasury Department closes in on his activities, and the body count starts to rise.
- DirectorDavid O. RussellStarsBradley CooperJennifer LawrenceRobert De NiroAfter a stint in a mental institution, former teacher Pat Solitano moves back in with his parents and tries to reconcile with his ex-wife. Things get more challenging when Pat meets Tiffany, a mysterious girl with problems of her own.
- DirectorPenny MarshallStarsRobert De NiroRobin WilliamsJulie KavnerThe victims of an encephalitis epidemic many years ago have been catatonic ever since, but now a new drug offers the prospect of reviving them.
- DirectorJames MangoldStarsWinona RyderAngelina JolieClea DuVallA directionless teenager, Susanna, is rushed to Claymoore, a mental institution, after a supposed suicide attempt. There, she befriends a group of troubled women who deeply influence her life.
- DirectorChristine JeffsStarsGwyneth PaltrowDaniel CraigLucy DavenportStory of the relationship between poets Edward James "Ted" Hughes and Sylvia Plath.
- DirectorJonathan DemmeStarsAnne HathawayRosemarie DeWittDebra WingerA young woman who has been in and out of rehab for the past ten years returns home for the weekend for her sister's wedding.
- DirectorFlorin SerbanStarsGeorge PistereanuAda CondeescuMihai ConstantinTwo weeks before his release, a teenage prisoner learns that his mother has returned home. Meanwhile, he finds himself in love with a student working in the penitentiary as an intern.
- DirectorJane CampionStarsKate WinsletHarvey KeitelJulie HamiltonRuth's been brainwashed by a guru in Delhi, India. Her parents in Sydney hire a specialist in reversing this. Ruth is tricked to return to Australia and is isolated in an outback cabin with the specialist. It gets messy.
- DirectorNancy BardawilStarsHilary DuffEvan RossMichael MurphyA suicidal and rebellious teenager is sent to live with her grandparents for the summer, where life takes an unexpected turn.
- DirectorRebecca MillerStarsRobin WrightAlan ArkinMike BinderAfter her much older husband forces a move to a suburban retirement community, Pippa Lee engages in a period of reflection and finds herself heading toward a quiet nervous breakdown.
- DirectorIngmar BergmanStarsHarriet AnderssonGunnar BjörnstrandMax von SydowRecently released from a mental hospital, Karin rejoins her emotionally disconnected family in their island home, only to slip from reality as she begins to believe she is being visited by God.
- DirectorPedro AlmodóvarStarsVictoria AbrilAntonio BanderasLoles LeónAn unbalanced but alluring former mental patient takes a porn star prisoner in the hopes of convincing her to marry him.
- DirectorTony BillBarry L. YoungStarsDudley MooreDaryl HannahPaul ReiserA bitter ad executive who has reached his breaking point lands in a mental institution, where his career actually begins to thrive with help from his fellow patients.
- DirectorSusan RohrerStarsKellie MartinMary SteenburgenDiane BakerWhen the matriarch of the family suddenly dies, her daughter inherits custody of her.
- DirectorMichael AptedStarsJodie FosterLiam NeesonNatasha RichardsonIn a remote woodland cabin, a small-town doctor discovers Nell - a beautiful young hermit-woman with many secrets.
- DirectorMichael Caton-JonesStarsSharon StoneDavid MorrisseyDavid ThewlisNovelist Catherine Tramell is once again in trouble with the law, and Scotland Yard appoints psychiatrist Dr. Michael Glass to evaluate her. Though, like Detective Nick Curran before him, Glass is entranced by Tramell and lured into a seductive game.
- DirectorJames MangoldStarsJohn CusackRay LiottaAmanda PeetStranded at a desolate Nevada motel during a nasty rain storm, ten strangers become acquainted with each other when they realize that they're being killed off one by one.
- DirectorTodd PhillipsStarsJoaquin PhoenixRobert De NiroZazie BeetzDuring the 1980s, a failed stand-up comedian is driven insane and turns to a life of crime and chaos in Gotham City while becoming an infamous psychopathic crime figure.
- DirectorSofia CoppolaStarsKirsten DunstJosh HartnettJames WoodsA group of male friends become obsessed with five mysterious sisters who are sheltered by their strict, religious parents in suburban Detroit in the mid 1970s.
- DirectorTerry GilliamStarsJeff BridgesRobin WilliamsAdam BryantA former radio DJ, suicidally despondent because of a terrible mistake he made, finds redemption in helping a deranged homeless man who was an unwitting victim of that mistake.
- The true story of Zelda Fitzgerald (and her famous husband F. Scott), the Jazz Age icons who lived large, soared high and crashed very hard.
- DirectorPat O'ConnorStarsNatasha RichardsonTimothy HuttonRutanya AldaFamous 1920s modernist US writer F. Scott Fitzgerald and his eccentric Flapper socialite wife Zelda Sayre's relationship began quite passionately, but he slowly fell into alcoholism and she was eventually diagnosed with schizophrenia.
- DirectorAndrei TarkovskyStarsNatalya BondarchukDonatas BanionisJüri JärvetA psychologist is sent to a station orbiting a distant planet in order to discover what has caused the crew to go insane.
- DirectorGeorge CukorStarsCharles BoyerIngrid BergmanJoseph CottenTen years after her aunt was murdered in their London home, a woman returns from Italy in the 1880s to resume residence with her new husband. His obsessive interest in the home rises from a secret that may require driving his wife insane.
- DirectorChristopher NolanStarsChristian BaleHeath LedgerAaron EckhartWhen the menace known as the Joker wreaks havoc and chaos on the people of Gotham, Batman must accept one of the greatest psychological and physical tests of his ability to fight injustice.
- DirectorVincente MinnelliGeorge CukorStarsKirk DouglasAnthony QuinnJames DonaldThe life of brilliant but tortured artist Vincent van Gogh.
- DirectorMike NicholsStarsElizabeth TaylorRichard BurtonGeorge SegalA bitter, aging couple, with the help of alcohol, use their young houseguests to fuel anguish and emotional pain towards each other over the course of a distressing night.