Niko Bellic comes to Liberty City, America to live the good life, but ends up having to assist his dangerously indebted cousin Roman with his financial troubles, by any (mostly illegal) means necessary.
Several new upstart gangs have been able to sweep in and make their mark on Stilwater. As leader of the Saints, you'll have to do whatever it takes to protect the members of your gang.
Desmond Miles is trained to become a modern-day Assassin through the resurrected memories of ancestor Ezio Auditore da Firenze, who uncovers a massive Templar conspiracy in Renaissance Italy leading to the new Pope.