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- CreatorCecelia AhernDonald ToddStarsChristina ApplegateJennifer EspositoKevin DunnA woman suffers from amnesia and is forced to find out who she really is.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorShana Goldberg-MeehanScott SilveriStarsMatt LeBlancPaulo CostanzoDrea de MatteoIn this spin-off of Friends (1994), Joey Tribbiani moves to Los Angeles to pursue his acting career.
- CreatorScott SilveriStarsMinnie DriverJohn Ross BowieCedric YarbroughThe family of a special-needs teen is good at dealing with the challenges he faces--and excellent at creating new ones.
- CreatorChuck LorreSteven MolaroStarsIain ArmitageZoe PerryLance BarberMeet a child genius named Sheldon Cooper (already seen as an adult in The Big Bang Theory (2007)) and his family. Some unique challenges face Sheldon, who is socially impaired.
- CreatorBonnie TurnerTerry TurnerStarsJohn LithgowJane CurtinKristen JohnstonA group of aliens is sent to Earth, disguised as a human family, to experience and report life on the third planet from the sun.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorJackie FilgoJeff FilgoStarsMatt LeBlancLiza SnyderMatt CookA dad finds out that parenting is harder than he thought after his wife goes back to work and he's left at home to take care of the kids.
- StarsBrendan O'CarrollPaddy HoulihanDanny O'CarrollMrs Brown and family open the doors to her feckin' house for a Saturday night brawl.
- CreatorMichael Patrick KingLisa KudrowStarsLisa KudrowLance BarberRobert Michael MorrisAn ex A-list celebrity attempts to rekindle the flame of her once prominent acting career with nothing but a camera crew and some determination.
- CreatorDan SchneiderStarsJennette McCurdyAriana GrandeCameron OcasioA pair of roommates start a baby-sitting service to earn extra cash.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorLinwood BoomerMichael GloubermanGary MurphyStarsFrankie MunizBryan CranstonJustin BerfieldA gifted young teen tries to survive life with his dimwitted, dysfunctional family.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoAspiring film actress Penny Teller moves into a Pasadena apartment across the hall from brilliant, but socially awkward, physicists Sheldon Cooper and Leonard Hofstadter and shows them how little they know about life outside of the lab.
- CreatorMitchell HurwitzStarsJason BatemanMichael CeraPortia de RossiLevel-headed son Michael Bluth takes over family affairs after his father is imprisoned. But the rest of his spoiled, dysfunctional family are making his job unbearable.
- CreatorDan BucatinskyLisa KudrowDon RoosStarsLisa KudrowDan BucatinskyJennifer Elise CoxAfter quitting her job in finance under dubious circumstances, the affluent and self-interested Fiona Wallice tries her hand at therapy - offering clients 3-minute sessions over the Internet in hopes of weeding out any unnecessary emotion.
- CreatorDavid KendallBob YoungStarsMelissa Joan HartJoey LawrenceTaylor SpreitlerAfter a family scandal leaves Mel, a local politician, in charge of her niece and nephew, she hires a man named Joe to become the family's male nanny, or "manny."
- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorJonathan SchmockNell ScovellStarsMelissa Joan HartCaroline RheaBeth BroderickSabrina is a normal teenager, except for one thing - she's a witch. Guided by her aunts, who come from a long line of witches, and Salem, a mischievous warlock doing penance as a cat, Sabrina continually struggles to harness her powers.
- CreatorDavid E. KelleyStarsRobin WilliamsSarah Michelle GellarJames WolkOut-of-the-box Simon Roberts runs an ad agency with his Type-A daughter Sydney.
- CreatorGemma BakerEddie GorodetskyChuck LorreStarsAllison JanneyAnna FarisMimi KennedyA newly sober single mom tries to pull her life together in Napa Valley while dealing with her wayward mother.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorEmily SpiveyStarsChristina ApplegateMaya RudolphWill ArnettTakes an irreverent look at parenthood through the point of view of an acerbic working mother, along with her stay-at-home husband and opinionated parents.
- CreatorElaine AronsonSam BobrickStarsMark-Paul GosselaarTiffani ThiessenDustin DiamondWhile the gang is no longer the 'it' crowd at Cal U, Slater balances 3 sports, Screech his extracurriculars, Kelly her crushes, and all manner of college parties, but most of the 2 years follow Zach growing up and winning Kelly's heart.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.